JUAN SHEN1,#, WEIYU ZHANG2,3,#, QINQIN JIN2,3,#, FUYU GONG4,#, HEPING ZHANG5, HONGLIANG XU5, JIEJIE LI2,3, HUI YAO2,3, XIYA JIANG2,3, YINTING YANG2,3, LIN HONG2,3, JIE MEI2,3, YANG SONG6,*, SHUGUANG ZHOU2,3,7,*
Oncology Research, Vol.32, No.2, pp. 339-351, 2024, DOI:10.32604/or.2023.030887
Abstract Background: Invasive breast carcinoma (BRCA) is associated with poor prognosis and high risk of mortality. Therefore, it is critical to identify novel biomarkers for the prognostic assessment of BRCA. Methods: The expression data of polo-like kinase 1 (PLK1) in BRCA and the corresponding clinical information were extracted from TCGA and GEO databases. PLK1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting. Single sample gene set enrichment analysis (ssGSEA) was performed to evaluate immune infiltration in the BRCA microenvironment, and the random forest (RF) and… More >
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