Ya-Li Gao*1, Zi-Shen Zhao†1, Ming-Yun Zhang*, Li-Jie Han*, Yu-Jin Dong‡, Bo Xu‡
Oncology Research, Vol.25, No.8, pp. 1391-1398, 2017, DOI:10.3727/096504017X14881559833562
Abstract Emerging evidence suggests that the long noncoding RNA (lncRNA) plasmacytoma variant translocation 1
(PVT1) gene is involved in the pathogenesis of cervical cancer. However, the potential mechanism is rarely
reported. Our study found that PVT1 was upregulated in cervical cancer tissue and cell lines. After transfecting PVT1 siRNA, the proliferation, migration, and invasion of cervical cancer cells were markedly decreased.
miRNA expression profiles demonstrate that miR-424 was markedly downregulated in cervical cancer tissue.
Bioinformatics analysis revealed that miR-424 was potentially targeted by PVT1, which was confirmed by
dual-luciferase reporter assay. Pearson’s correlation analysis showed that More >
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