Seo Yeon Shin1, Nu Ri Song1, Sa Rang Choi1, Ki Min Kim1, Jae Hee Byun1, Su Jung Kim2, Dai Hyun Jung2, Seong Sim Kim2, Seong Ju Park2, So Jeong Chu2, Kyung Mok Park1,*
BIOCELL, Vol.49, No.8, pp. 1435-1448, 2025, DOI:10.32604/biocell.2025.065199
- 29 August 2025
Abstract Background: The efficient transdermal delivery of biologically active molecules remains a major challenge because of the structural barrier of the stratum corneum, which limits the penetration of large or hydrophilic molecules. Low-molecular-weight protamine (LMWP) has a structure similar to that of the HIV TAT protein-derived peptide and is a representative cell-penetrating peptide (CPP) used to increase cell permeability. However, protamine has been reported to have many toxicities and side effects. Objectives: We developed human-derived low-molecular-weight protamine (hLMWP), which is based on fish-derived LMWP but designed using human protein sequences to improve safety and functionality. As… More >
Graphic Abstract