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  • Open Access

    REVIEW

    A Review on Novel Applications of Nanoparticles in Pediatric Oncology

    Theano Makridou1, Elena Vlastou2, Vasilios Kouloulias3, Efstathios P. Efstathopoulos4, Kalliopi Platoni4,*

    Oncology Research, Vol.33, No.12, pp. 3611-3632, 2025, DOI:10.32604/or.2025.069101 - 27 November 2025

    Abstract Nanomedicine has evolved significantly over the last decades and expanded its applications in pediatric oncology, which represents a special domain with unique patients and distinct requirements. Τhe need for early cancer diagnosis and more effective and targeted therapies aiming to increase the pediatric patients’ survival rates and minimize the treatment-related side effects to survivors is profound. Nanoparticles (NPs) come as a beacon of hope to provide sensitive cancer diagnostic tools and assist contrast agents’ transport to the malignant tumors. Besides, NPs could be designed to deliver targeted drugs and genes to tumors, minimizing the medicine-related… More >

  • Open Access

    ARTICLE

    Implementation of a Pediatric Oncology Precision Medicine Clinic to Personalize Approaches for Diagnosing and Treating Solid Tumors

    Madeline Keane1, Natalia Wojciechowska2, Lindsay Zumwalt1,*, Emilie Sandfeld3, Alejandra Dominguez1, Jason Wang2, Anish Ray2

    Oncology Research, Vol.33, No.8, pp. 1895-1908, 2025, DOI:10.32604/or.2025.065547 - 18 July 2025

    Abstract Background: Precision medicine is an emerging approach for treating pediatric cancer due to its ability to target tumor-specific genetic drivers rather than provide broad and aggressive treatments. The study aimed to outline the establishment and impact of a Precision Medicine Clinic (PMC) in the setting of pediatric oncology, with the objective of offering targeted treatment options within the institution and creating a scalable model for adoption by other healthcare systems to achieve a wider impact. Methods: Recognizing this need for an individualized approach to treating patients, Cook Children’s Medical Center (CCMC) established a multidisciplinary molecular… More >

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