XUEJIA ZHAI1,2,3,4,#, JIE LIU2,3,4,#, JINWEI XIAO2,3,4, TAO ZHANG2,3,4, JUN WANG2,3,4,5, JIANJUN LI1,*, SHICANG YU2,3,4,5,*
BIOCELL, Vol.48, No.8, pp. 1223-1239, 2024, DOI:10.32604/biocell.2024.050803
Abstract Background: Protein lactylation is a new way for the “metabolic waste” lactic acid to perform novel functions. Nevertheless, our understanding of the contribution of protein lactylation to both tumor progression and therapeutic interventions remains imited. The construction of a scoring system for lactylation to predict the prognosis of pan-cancer patients and to evaluate the tumor immune microenvironment (TIME) would improve our understanding of the clinical significance of lactylation. Methods: Consensus clustering analysis of lactylation-related genes was used to cluster 177 pancreatic adenocarcinoma (PAAD) patients. Subsequently, a scoring system was developed using the least absolute shrinkage… More >
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