Yanjie Han^*1, Xinxin Li^*1, Fei He^†1, Jiliang Yan^*, Chunyan Ma^*, Xiaoli Zheng^‡, Jinli Zhang^*, Donghui Zhang^*, Cuiping Meng^*, Zhen Zhang^*, Xinying Ji^§

Oncology Research, Vol.27, No.6, pp. 681-690, 2019, DOI:10.3727/096504018X15424939990246

Abstract Plasmacytoma variability translocation 1 (PVT1), an oncogene, has been reported to be highly expressed in many tumors, including human glioma, gastric cancer, and non-small cell lung cancer. Functionally, it could also regulate the development of tumor cells. However, its specific roles and pathogenesis in human gliomas are still not clear. This study investigated the function and mechanism of PVT1 knockdown in the proliferation and malignant transformation of human gliomas. We first examined the expression levels of PVT1 and miR- 424 in human glioma tissues and cell lines. We also used gene manipulation techniques to explore… More >

Bao-Juan Wang^*, Hong-Wei Ding^†, Guo-An Ma^†

Oncology Research, Vol.26, No.5, pp. 675-681, 2018, DOI:10.3727/096504017X14920318811730

Abstract Melanoma is an extremely aggressive malignant skin tumor with a high mortality. Various long noncoding RNAs (lncRNAs) have been reported to be associated with the oncogenesis of melanoma. The purposes of this study were to investigate the potential role of lncRNA PVT1 in melanoma progression and to explore its possible mechanisms. A total of 35 patients who were diagnosed with malignant melanoma were enrolled in this study. Expression of PVT1 was significantly upregulated in melanoma tissue and was associated with a poor prognosis. Loss-of-function experiments showed that PVT1 knockdown markedly suppressed the proliferation activity, induced More >

Ya-Li Gao^*1, Zi-Shen Zhao^†1, Ming-Yun Zhang^*, Li-Jie Han^*, Yu-Jin Dong^‡, Bo Xu^‡

Oncology Research, Vol.25, No.8, pp. 1391-1398, 2017, DOI:10.3727/096504017X14881559833562

Abstract Emerging evidence suggests that the long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) gene is involved in the pathogenesis of cervical cancer. However, the potential mechanism is rarely reported. Our study found that PVT1 was upregulated in cervical cancer tissue and cell lines. After transfecting PVT1 siRNA, the proliferation, migration, and invasion of cervical cancer cells were markedly decreased. miRNA expression profiles demonstrate that miR-424 was markedly downregulated in cervical cancer tissue. Bioinformatics analysis revealed that miR-424 was potentially targeted by PVT1, which was confirmed by dual-luciferase reporter assay. Pearson’s correlation analysis showed that More >