GERHARD HAMILTON^*, MARIE-THERESE EGGERSTORFER, SANDRA STICKLER

Oncology Research, Vol.32, No.8, pp. 1257-1264, 2024, DOI:10.32604/or.2024.051653

Abstract The Kirsten rat sarcoma virus—son of sevenless 1 (KRAS-SOS1) axis drives tumor growth preferentially in pancreatic, colon, and lung cancer. Now, KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of KRAS. However, the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%, lasting for a mean period of 8 months. One approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras (PROTACs), which… More > Graphic Abstract

Jin Tao¹, Jiatai Tian¹, Dongmei Li¹, Jinlei Zhu², Qun Ma³, Zhiming Zhang¹, Jungang Chen⁴, Yipeng Liu⁵, Jianqiang Qian^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1129-1141, 2024, DOI:10.32604/phyton.2024.051405

Abstract Human activities and industrialization have significantly increased soil nutrients, such as nitrogen (N) and phosphorus (P), profoundly impacting the composition and structure of plant community, as well as the ecosystem functions, especially in nutrient-limited ecosystems. However, as the key propagule pool of perennial grasslands, how belowground bud bank and its relationship with aboveground vegetation respond to short-term changes in soil nutrients was still unclear. In this study, we conducted a short-term (2021–2022) soil fertilization experiment with N addition (10 g N m yr) and P addition (5 g N m yr) in the meadow steppe… More >

Cheng Yang^1,2, Miaojia Lou^2,*, Xiaoyu Chen^1,2, Zixuan Ren¹

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4107-4126, 2024, DOI:10.32604/cmc.2024.049183

Abstract Chinese shadow puppetry has been recognized as a world intangible cultural heritage. However, it faces substantial challenges in its preservation and advancement due to the intricate and labor-intensive nature of crafting shadow puppets. To ensure the inheritance and development of this cultural heritage, it is imperative to enable traditional art to flourish in the digital era. This paper presents an Interactive Collaborative Creation System for shadow puppets, designed to facilitate the creation of high-quality shadow puppet images with greater ease. The system comprises four key functions: Image contour extraction, intelligent reference recommendation, generation network, and… More >

Shenggang Liu^*, Hongzhong Yang^†, Ying Chen^‡, Baimei He^§, Qiong Chen^§

Oncology Research, Vol.24, No.2, pp. 81-87, 2016, DOI:10.3727/096504016X14597766487717

Abstract In order to improve therapeutic efficacy, it is a current emergency to better know the mechanisms underlying cisplatin resistance in lung cancer cells. In this study, we aim to investigate the role of Krüppel-like factor 4 (KLF4) in cisplatin-resistant lung cancer cells. We developed cisplatin-resistant lung cancer cell line A549/ DDP, and then a battery of experiments was used to analyze the effects of KLF4 in cisplatin resistance of lung cancer. We found that KLF4 was significantly downregulated in cisplatin-resistant A549 cells and forced KLF4 expression inhibited cell growth and induced apoptosis. Further, we found More >

Zhangjie Jiang^*1, Yida Zhang^†1, Runfu Cao^†, Li Li^‡, Kezhao Zhong^†, Qingsheng Chen^†, Jianjun Xiao^†

Oncology Research, Vol.25, No.7, pp. 1081-1087, 2017, DOI:10.3727/096504016X14831120463349

Abstract miRNAs play a key role in the carcinogenesis of many cancers, including bladder cancer. In the current study, the role of miR-5195-3p, a quite recently discovered and poorly studied miRNA, in the proliferation and invasion of human bladder cancer cells was investigated. Our data displayed that, compared with healthy volunteers (control) and SU-HUC-1 normal human bladder epithelial cells, miR-5195-3p was sharply downregulated in bladder cancer patients and five human bladder cancer cell lines. The oligo miR-5195-3p mimic or miR-5195-3p antagomir was subsequently transfected into both T24 and BIU-87 bladder cancer cell lines. The miR-5195-3p mimic… More >

Jing Wang^1,#, Wenqing Xiao^1,#, Qingnan Wang¹, Xu Wang¹, Bin Jiang¹, Yangchun Han², Yang Sun^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 859-873, 2024, DOI:10.32604/phyton.2024.048151

Abstract The basic leucine zipper (bZIP) is an important class of transcription factors in plants, playing a critical role in plant growth and development and responses to biotic and abiotic stress. Due to gene presence/absence variations, it is limited to identify bZIP genes based on the reference genome. Therefore, we performed the bZIP gene family analysis in the rice pan-genome. By employing a rice pan-genome, ninety-four OsbZIPs (72 core genes and 22 variable genes) were identified and divided into 11 groups in a phylogenetic tree. Based upon Ka/Ks values in 33 accessions, OsbZIPs were subjected to different selection… More >

P. Pai Nityanand, B. Devaki, G. Bhat Pareekshith, V. S. Sampath Kumar^*

Frontiers in Heat and Mass Transfer, Vol.22, No.2, pp. 655-673, 2024, DOI:10.32604/fhmt.2024.050237

Abstract The study in this manuscript aims to analyse the impact of thermal radiation on the two-dimensional magnetohydrodynamic flow of upper convected Maxwell (UCM) fluid between parallel plates. The lower plate is porous and stationary, while the top plate is impermeable and moving. The equations that describe the flow are transformed into non-linear ordinary differential equations with boundary conditions by employing similarity transformations. The Homotopy Perturbation Method (HPM) is then employed to approach the obtained non-linear ordinary differential equations and get an approximate analytical solution. The analysis includes plotting the velocity profile for different Reynolds number… More >

Kadhum Audaa Jehhef¹, Ali J. Ali², Salah H. Abid Aun¹, Akram H. Abed^3,*

Frontiers in Heat and Mass Transfer, Vol.22, No.2, pp. 557-581, 2024, DOI:10.32604/fhmt.2024.047814

Abstract The cavity with lid-driven is greatly used in mixing, coating, and drying applications and is a substantial issue in the study of thermal performance rate and fluid field. A numerical approach is presented to study the thermal distribution and passage of fluid in a lid-driven cavity with an upper oscillating surface and an attached baffle. The walls of a cavity at the left and right were maintained at 350 and 293 K, respectively. The upper oscillating surface was equipped with a variable height to baffle to increase the convection of the three kinds of TiO,… More >

Yiming Tang^1,2, Jianwei Gao^1,*, Yifan Huang¹

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1063-1088, 2024, DOI:10.32604/cmc.2024.049341

Abstract The α-universal triple I (α-UTI) method is a recognized scheme in the field of fuzzy reasoning, which was proposed by our research group previously. The robustness of fuzzy reasoning determines the quality of reasoning algorithms to a large extent, which is quantified by calculating the disparity between the output of fuzzy reasoning with interference and the output without interference. Therefore, in this study, the interval robustness (embodied as the interval stability) of the α-UTI method is explored in the interval-valued fuzzy environment. To begin with, the stability of the α-UTI method is explored for the… More >

Parth Khandelwal¹, Harshit², Indranil Manna^1,3,*

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1727-1755, 2024, DOI:10.32604/cmc.2024.042752

Abstract Metallic alloys for a given application are usually designed to achieve the desired properties by devising experiments based on experience, thermodynamic and kinetic principles, and various modeling and simulation exercises. However, the influence of process parameters and material properties is often non-linear and non-colligative. In recent years, machine learning (ML) has emerged as a promising tool to deal with the complex interrelation between composition, properties, and process parameters to facilitate accelerated discovery and development of new alloys and functionalities. In this study, we adopt an ML-based approach, coupled with genetic algorithm (GA) principles, to design… More > Graphic Abstract