DIMITRA P. VAGELI^1,2,*, PANAGIOTIS G. DOUKAS³, KERASIA GOUPOU², ANTONIOS D. BENOS², KYRIAKI ASTARA^2,4, KONSTANTINA ZACHAROULI², SOTIRIS SOTIRIOU⁵, MARIA IOANNOU²

Oncology Research, Vol.32, No.8, pp. 1239-1256, 2024, DOI:10.32604/or.2024.052130

Abstract Glioblastoma multiforme (GBM) is an aggressive primary brain tumor characterized by extensive heterogeneity and vascular proliferation. Hypoxic conditions in the tissue microenvironment are considered a pivotal player leading tumor progression. Specifically, hypoxia is known to activate inducible factors, such as hypoxia-inducible factor 1alpha (HIF-1α), which in turn can stimulate tumor neo-angiogenesis through activation of various downward mediators, such as the vascular endothelial growth factor (VEGF). Here, we aimed to explore the role of HIF-1α/VEGF immunophenotypes alone and in combination with other prognostic markers or clinical and image analysis data, as potential biomarkers of GBM prognosis… More >

Qingran Meng^1,2, Wenwen Xu², Zuobing Xiao², Qinfei Ke^1,2,*, Xingran Kou^1,2,*

Journal of Renewable Materials, Vol.12, No.4, pp. 629-641, 2024, DOI:10.32604/jrm.2023.029182

Abstract Bio-based cyclodextrins (CDs) are a common research object in supramolecular chemistry. The special cavity structure of CDs can form supramolecular self-assemblies such as vesicles and microcrystals through weak interaction with guest molecules. The different forms of supramolecular self-assemblies can be transformed into each other under certain conditions. The regulation of supramolecular self-assembly is not only helpful to understand the self-assembly principle, but also beneficial to its application. In the present study, the self-assembly behavior of epoxy-β-cyclodextrin (EP-β-CD) and mixed anionic and cationic surfactant system (sodium dodecyl sulfate/dodecyltrimethylammonium bromide, SDS/DTAB) in aqueous solution was studied. Morphological… More > Graphic Abstract

Camden L. Hebson^1,*, Kyle Bliton², Amr Y. Hammouda¹, Kaitlyn Barr³, W. Hampton Gray⁴, Mohini Gunnett², Waldemar F. Carlo¹

Congenital Heart Disease, Vol.19, No.2, pp. 185-195, 2024, DOI:10.32604/chd.2024.048871

Abstract D-transposition of the great arteries (d-TGA) is surgically repaired with the arterial switch operation (ASO) with excellent results, however short and long-term morbidities still develop including neurocognitive delay. Clinically significant central sleep apnea is uncommon in non-premature infants, but when present indicates immature autonomic control of respiration likely due to a neurologic disorder. We report the unanticipated finding of central sleep apnea in four-term neonates with d-TGA after uncomplicated ASO, with the short-term complication of delayed hospital discharge and long-term concerns regarding this early marker of brain immaturity and its hindrance to normal development. Within More >

ALEKSANDRA GORNOSTAEVA, LUDMILA BURAVKOVA, MARGARITA LOBANOVA, ELENA ANDREEVA^*

BIOCELL, Vol.48, No.5, pp. 677-692, 2024, DOI:10.32604/biocell.2024.048873

Abstract The structural and associated molecules of the extracellular matrix (ECM) complex is an important component of the local milieu of cells, both for maintaining their functions and homeostasis. It is a dynamic structure that is finely tuned to changes in the microenvironment. One of these factors is hypoxia, which can arise in tissues due to physiological or pathological effects. As a result of the hypoxic effect, the properties of the ECM are significantly modified, stiffness increases, the balance between degradation and synthesis of structural proteins shifts, and the deposition of biologically active mediators’ changes. Hypoxia-inducible… More >

Lei Zhu^1,#, Lihe Hou^1,3,#, Yu Zhang¹, Yang Jiang¹, Yi Wang^1,2, Meiping Zhang^1,2, Mingzhu Zhao^1,2,*, Kangyu Wang^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 313-327, 2024, DOI:10.32604/phyton.2024.047938

Abstract Panax ginseng C. A. Mey. is an important plant species used in traditional Chinese medicine, whose primary active ingredient is a ginsenoside. Ginsenoside biosynthesis is not only regulated by transcription factors but also controlled by a variety of structural genes. Nonetheless, the molecular mechanism underlying ginsenoside biosynthesis has always been a topic in the discussion of ginseng secondary metabolites. Squalene epoxidase (SQE) is a key enzyme in the mevalonic acid pathway, which affects the biosynthesis of secondary metabolites such as terpenoid. Using ginseng transcriptome, expression, and ginsenoside content databases, this study employed bioinformatic methods to systematically… More >

PARSOTAM H. PARSANIA^1,*, JIGNESH V. PATEL², JIGNESH P. PATEL³

Journal of Polymer Materials, Vol.40, No.3-4, pp. 271-284, 2023, DOI:10.32381/JPM.2023.40.3-4.9

Abstract Bisphenol-C epoxy crotonate resin was synthesized by reacting 8.09g epoxy resin of bisphenolC, and 2.15g crotonic acid using 25 mL 1,4-dioxane as a solvent, and 1 mL triethylamine as a catalyst at reflux temperature for 1-6 h. Solid epoxy crotonate (ECCR) is highly soluble in common organic solvents. ECCR was characterized by its acid (24.5-1.5 mg KOH/g) and hydroxyl (504.5-678.4 mg KOH/g) values. The structure of ECCR is supported by FTIR and 1 HNMR spectroscopic methods. A DSC endothermic transition at 229o C indicated melting followed by thermal polymerization of ECCR. ECCR is thermally stable… More >

K. KRISHNAMOORTHY^a,*, N. PRABHU^b

Journal of Polymer Materials, Vol.40, No.3-4, pp. 215-226, 2023, DOI:10.32381/JPM.2023.40.3-4.7

Abstract The acoustic emission monitoring with artificial neural networks predicts the ultimate strength of glass/epoxy composite laminates using Acoustic Emission Data. The ultimate loads of all the specimens were used to characterise the emission of hits during failure modes. The six layered glass fiber laminates were prepared (in woven mat form) with epoxy as the binding medium by hand lay-up technique. At room temperature, with a pressure of 30 kg/cm², the laminates were cured. The laminates of standard dimensions as per ASTM D3039 for the tensile test were cut from the lamina. The Acoustic Emission (AE) test More >

HADIMANI SHIVAKUMAR¹, GURUMURTHY G. D.¹, BOMMEGOWDA K. B.², S. PARAMESHWARA³

Journal of Polymer Materials, Vol.40, No.1-2, pp. 93-103, 2023, DOI:10.32381/JPM.2023.40.1-2.8

Abstract Polymer composites are increasing in demand in energy storage applications including in the electronic as well as electrical industries due to the ease of processing of these materials with associated advantages like light weight, corrosion resistance, and high mechanical strength. In this investigation, efforts are made to enhance the charging and discharging properties of epoxy/carbon fabric composite by the addition of graphene nanoplatelets (GNPs) into the epoxy/ carbon matrix. The performance of the composites with graphene platelets of 0.5 to 5 wt. % in epoxy were characterized and 1wt.% percolation threshold was observed poor performance… More >

Rizwan Iqbal^1,*, Rashid Hussain², Sheeraz Arif³, Nadia Mustaqim Ansari⁴, Tayyab Ahmed Shaikh²

CMC-Computers, Materials & Continua, Vol.77, No.2, pp. 1575-1598, 2023, DOI:10.32604/cmc.2023.042432

Abstract Software-Defined Networking (SDN) is a new network technology that uses programming to complement the data plane with a control plane. To enable safe connection, however, numerous security challenges must be addressed. Flooding attacks have been one of the most prominent risks on the internet for decades, and they are now becoming challenging difficulties in SDN networks. To solve these challenges, we proposed a unique firewall application built on multiple levels of packet filtering to provide a flooding attack prevention system and a layer-based packet detection system. This study offers a systematic strategy for wrapping up… More >

JING LI^1,2, WANWAN FAN⁴, LILI HAO¹, YONGSHENG LI⁵, GUOCHENG YU¹, WEI SUN⁶, XIANQIONG LUO^2,*, JINGXIANG ZHONG^1,3,*

BIOCELL, Vol.47, No.11, pp. 2485-2494, 2023, DOI:10.32604/biocell.2023.044177

Abstract Objective: This study aimed to investigate the potential of human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomes (hucMSC-Exos) in inhibiting hypoxia-induced cell hyper proliferation and overexpression of vascular endothelial growth factor A (VEGF-A) in immature human fetal retinal microvascular endothelial cells (hfRMECs). Methods: Exosomes were isolated from hucMSCs using cryogenic ultracentrifugation and characterized through various techniques, including transmission electron microscopy, nanoparticle tracking analysis, bicinchoninic acid assays, and western blotting. The hfRMECs were identified using von Willebrand factor (vWF) co-staining and divided into four groups: a control group cultured under normoxic condition, a hypoxic model group, a hypoxic… More > Graphic Abstract