WEITAO ZHENG¹, DONG JIANG², SONGEN CHEN¹, MEILING WU¹, BAOQI YAN², JIAHUI ZHAI², YUNQIANG SHI², BIN XIE¹, XINGWANG XIE², KANGHONG HU^1,*, WENXUE MA^3,*

Oncology Research, Vol.32, No.12, pp. 1837-1850, 2024, DOI:10.32604/or.2024.056565 - 13 November 2024

Abstract Objectives: The Kirsten rat sarcoma virus (KRAS) G12D oncogenic mutation poses a significant challenge in treating solid tumors due to the lack of specific and effective therapeutic interventions. This study aims to explore innovative approaches in T cell receptor (TCR) engineering and characterization to target the KRAS G12D_7-16 mutation, providing potential strategies for overcoming this therapeutic challenge. Methods: In this innovative study, we engineered and characterized two T cell receptors (TCRs), KDA11-01 and KDA11-02 with high affinity for the KRAS G12D_7-16 mutation. These TCRs were isolated from tumor-infiltrating lymphocytes (TILs) derived from tumor tissues of patients More >

Yuhong Zhao^1,2,3,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.012951

Abstract For a long time, the phase-field method has been considered as a mesoscale phenomenological method lacking physical accuracy and unable to be associated with the mechanical/functional properties of materials, etc. Some misunderstandings existing in these viewpoints need to be clarified. Therefore, it is necessary to propose or adopt the perspective of “unified or unifying phase-field modeling (UPFM)” to address these issues, which means that phase-field modeling has multiple unifications. Specifically, the phase-field method is the perfect unity of thermodynamics and kinetics, the unity of multi-scale models from micro- to meso- and then to macroscopic scale, More >

Yongbing Li^1,*, Yunwu Ma¹, Yujun Xia¹, Ming Lou¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.012602

Abstract The implementation of lightweight materials and structures in automotive body manufacturing is a strategic approach to improve fuel efficiency of energy-efficient vehicles and driving range of new energy vehicles. However, high specific strength low-ductility light metals (like 7xxx aluminum, magnesium and cast aluminum), ultra-high strength steels, high-stiffness profile structures and their mixed use poses a big challenge to existing commercial spot joining processes, such as resistance spot welding and self-piercing riveting. In this talk, the challenges which new lightweight materials and structures pose to spot joining process will be presented, the bottleneck of the existing More >

JYOTHI B. NAIR^1,2, ANU MARY JOSEPH³, SANOOP P.⁴, MANU M. JOSEPH^5,*

BIOCELL, Vol.48, No.11, pp. 1579-1602, 2024, DOI:10.32604/biocell.2024.054879 - 07 November 2024

Abstract Nanoparticles represent a heterogeneous collection of materials, whether natural or synthetic, with dimensions aligning in the nanoscale. Because of their intense manifestation with the immune system, they can be harvested for numerous bio-medical and biotechnological advancements mainly in cancer treatment. This review article aims to scrutinize various types of nanoparticles that interact differently with immune cells like macrophages, dendritic cells, T lymphocytes, and natural killer (NK) cells. It also underscores the importance of knowing how nanoparticles influence immune cell functions, such as the production of cytokines and the presentation of antigens which are crucial for… More >

Chenchen Zhou^1,2, Shuaishuai Liang³, Bin Qi³, Chenxu Liu², Nam-Joon Cho^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-2, 2024, DOI:10.32604/icces.2024.012380

Abstract Micro tools/parts are attracting increasing attention due to the miniaturization evolutionary tendency in many fields, whose functionalities are critically determined by their materials and shapes [1- 5]. Sharp-edged ceramic microparticles have great prospects to be used as micromachining tools and micro components. However, it remains a huge challenge to fabricate nontransparent ceramic sharp-edged microparticles in a high-throughput way while taking their shape complexity, precision, and strength into account [6-8]. Herein, we present an online mixing and in-situ polymerization strategy: “one-pot microfluidic fabrication” along with two novel microfluidic device fabrication methods: “groove & tongue” and sliding More >

Fajri Marindra Siregar^1,2, Sofia Mubarika Haryana³, Dyah Wulan Anggrahini⁴, Lucia Kris Dinarti⁴, Anggoro Budi Hartopo^4,*

Congenital Heart Disease, Vol.19, No.4, pp. 375-388, 2024, DOI:10.32604/chd.2024.054742 - 31 October 2024

Abstract A particular type of endogenous noncoding RNAs known as circular RNAs (circRNAs) has now become possible biomarkers for several diseases because of their stability and tissue-specific expression patterns. CircRNAs might play a role in various of biological processes. The identification of particular circRNAs dysregulated in pulmonary arterial hypertension (PAH) raises the possibility of these molecules serving as biomarkers for the disease’s early diagnosis and treatment. This review mainly summarizes the role and potential of circRNA as a future biomarker in PAH related to congenital heart disease. This study presented several potential circRNA targets as diagnostic More > Graphic Abstract

Yanhuan Lin^1,#, Jiaxin Feng^2,#, Hao Fang², Wei Huang², Kanglie Guo², Xiyan Liu², Shuqi Wang², Xiaojuan Liu^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2583-2596, 2024, DOI:10.32604/phyton.2024.055616 - 30 October 2024

Abstract Heat shock transcription factor (HSF) are essential regulators of heat shock protein (HSP) gene expression in plants and algae, contributing to their resilience against biotic and abiotic stresses. However, the localization, structure, phylogenetic relationship, and characteristics of PtHSF genes in microalgae, especially in diatom Phaeodactylum tricornutum, remain largely unexplored. This study presents a comprehensive analysis of the PtHSF gene family in P. tricornutum. A genome-wide analysis identified 68 PtHSF genes, which were classified into two distinct subfamilies: traditional and untraditional. Motif and structure analyses revealed evidence of multiple duplication events within the PtHSF gene family. Expression profiling revealed diurnal… More >

Jianan Wang^1,*, Yikuan Fan², Weidong Duan³, Zhaopeng Song¹

Energy Engineering, Vol.121, No.11, pp. 3401-3415, 2024, DOI:10.32604/ee.2024.055158 - 21 October 2024

Abstract Since pure tobacco stalk (TS) biomass pellet fuels tend to slag, five anti-slagging agents were added to the crushed TS to obtain a pellet fuel that could be used in biomass burners to provide heat for tobacco curing. The obtained results revealed that the main component of TS pellet fuel was K₂Si₂O₅. During fuel combustion process, additives generated higher melting point silicate compounds by Al–K, Ca–K, and Ca–K elemental structures to replace single K elemental structure of TS, enhancing the anti-slagging efficiency of the pellet fuel from 21.63% to 78.29% and promoting the precipitation of K, More >

JINXIA CHEN^1,2,3,#, SULI DAI^1,2,#, GENG ZHANG^4,5, SISI WEI^1,2, XUETAO ZHAO³, YANG ZHENG^1,2, YAOJIE WANG^1,2, XIAOHAN WANG^1,2, YUNJIANG LIU^4,5,*, LIANMEI ZHAO^1,2,*

Oncology Research, Vol.32, No.11, pp. 1791-1802, 2024, DOI:10.32604/or.2024.049348 - 16 October 2024

Abstract Background: Triple-negative breast cancer (TNBC) is a heterogeneous, recurring cancer characterized by a high rate of metastasis, poor prognosis, and lack of efficient therapies. KBU2046, a small molecule inhibitor, can inhibit cell motility in malignant tumors, including breast cancer. However, the specific targets and the corresponding mechanism of its function remain unclear. Methods: In this study, we employed (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H tetrazolium) (MTS) assay and transwell assay to investigate the impact of KBU2046 on the proliferation and migration of TNBC cells in vitro. RNA-Seq was used to explore the targets of KBU2046 that inhibit the motility of TNBC.… More > Graphic Abstract

Anuraag Moturi, Dharmesh R. Chejara^*

Journal of Polymer Materials, Vol.41, No.3, pp. 179-190, 2024, DOI:10.32604/jpm.2024.055887 - 30 September 2024

Abstract A chitosan and guar protein isolate blend conjugate (Ch/GPI-Glu) based membrane has been designed and studied for its possible interaction with this biopolymer mixture. The designed conjugate chitosan/guar protein isolate blended membrane was investigated for its structural features using Fourier Transform Infrared Spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA), X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) analyses. IR Spectroscopic data suggested that chitosan and guar protein isolate contributed to a specific intermolecular interaction. The designed membrane was water-insoluble and it exhibited strong polymer–protein interaction. Further, the membrane was also found to have a smooth morphology More >