Junhui Yan¹, Yawen Wang¹, Qiong Li¹, Yu Zhou², Xu Wang^2,*, Li Luo^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1237-1248, 2024, DOI:10.32604/phyton.2024.051517

Abstract Rhizobia induces nitrogen-fixing nodules in legumes used in agricultural production, providing a direct source of combined nitrogen to leguminous crops. Small peptides, such as CLAVATA3/EMBRYO SURROUNDING REGION peptides (CLE), are known to regulate the formation and development of nitrogen-fixing nodules in legumes. Root meristem growth factor (RGF) peptides from Medicago truncatula not only regulate root development but also modulate nodulation symbiosis with Sinorhizobium meliloti. However, the impact of RGF peptides from one leguminous species on the others remains unclear. In this study, we investigate the effects of the RGF family peptide MtRGF6p from M. truncatula on nodulation symbiosis… More >

Marya Iqbal¹, Yaser Hafeez¹, Nabil Almashfi², Amjad Alsirhani³, Faeiz Alserhani⁴, Sadia Ali¹, Mamoona Humayun^5,*, Muhammad Jamal⁶

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 5031-5049, 2024, DOI:10.32604/cmc.2024.051371

Abstract Embracing software product lines (SPLs) is pivotal in the dynamic landscape of contemporary software development. However, the flexibility and global distribution inherent in modern systems pose significant challenges to managing SPL variability, underscoring the critical importance of robust cybersecurity measures. This paper advocates for leveraging machine learning (ML) to address variability management issues and fortify the security of SPL. In the context of the broader special issue theme on innovative cybersecurity approaches, our proposed ML-based framework offers an interdisciplinary perspective, blending insights from computing, social sciences, and business. Specifically, it employs ML for demand analysis, More >

Fang Li^1,*, Juan Wu¹, Haiyong Yi², Lihong Wu², Lingyun Du¹, Yuan Zeng¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1015-1030, 2024, DOI:10.32604/fdmp.2023.043256

Abstract Methods for horizontal well spacing calculation in tight gas reservoirs are still adversely affected by the complexity of related control factors, such as strong reservoir heterogeneity and seepage mechanisms. In this study, the stress sensitivity and threshold pressure gradient of various types of reservoirs are quantitatively evaluated through reservoir seepage experiments. On the basis of these experiments, a numerical simulation model (based on the special seepage mechanism) and an inverse dynamic reserve algorithm (with different equivalent drainage areas) were developed. The well spacing ranges of Classes I, II, and III wells in the Q gas More > Graphic Abstract

Rui Jiang^*, Chao Zhang^†, Guangyao Liu^*, Rui Gu^*, Han Wu^*

Oncology Research, Vol.25, No.8, pp. 1409-1419, 2017, DOI:10.3727/096504017X14882829077237

Abstract Osteosarcoma is the most common primary bone malignancy manifested predominantly in children and young adults. Studies indicate that miR-107 is involved in the pathogenesis of osteosarcoma and that tropomyosin 1 (TPM1) acts as a tumor suppressor in many types of cancer. In this study, we analyzed the effect of miR-107 on human osteosarcoma cells and investigated the mechanism in which TPM1 is involved. miR-107 expression in human osteosarcoma tissues and cells was analyzed in quantitative real-time PCR (qRT-PCR). Human osteosarcoma (U2OS) cells were transfected with miR-107 mimic, inhibitor, or scramble controls to evaluate the effect… More >

Chengyan Luo, Jiangnan Qiu

Oncology Research, Vol.25, No.8, pp. 1341-1348, 2017, DOI:10.3727/096504017X14867268787969

Abstract Cervical cancer is among the most common cancers inflicting women worldwide. Understanding the pathological mechanisms of cervical cancer development is critical for identifying novel targets for cervical cancer treatment. MicroRNAs (miRs) have various roles in regulating cancer development. In this study, we investigated the potential role of miR-181a and its target in regulating cervical cancer development and chemotherapy resistance. The expression of miR-181a was evaluated and modulated in several human cervical cancer cell lines. The role of miR-181a in regulating cervical cancer growth and chemotherapy sensitivity was investigated in cell culture models and mouse tumor… More >

Xin Zhang^*, Shaowen Li^†, Chunli Dong^‡, Xiuying Xie^*, Yunping Zhang^*

Oncology Research, Vol.25, No.2, pp. 259-265, 2017, DOI:10.3727/096504016X14732503870766

Abstract Ovarian cancer is one of the leading causes of gynecological cancer-related deaths worldwide. We investigated the role of a newly discovered long noncoding RNA, NR_026689, in cell proliferation, metastasis, and apoptosis in ovarian cancer cells. Our results showed that NR_026689 was overexpressed in both clinical ovarian cancer patients and cultured ovarian cancer cells. Knockdown of NR_026689 in HO-8910PM cells significantly decreased the cell proliferative rate and the ability to form colonies. Transwell assays revealed that depletion of NR_026689 suppressed cell migration ability by 68% and cell invasive capacity by 71% in HO-8910PM cells. Moreover, specific More >

Chun-ming Yang^*, Shan Ji^†, Yan Li^‡, Li-ye Fu^‡, Tao Jiang^‡, Fan-dong Meng^‡

Oncology Research, Vol.25, No.2, pp. 195-205, 2017, DOI:10.3727/096504016X14732772150424

Abstract Renal cell carcinoma (RCC) represents one of the most resistant tumors to radiation and chemotherapy. Current therapies for RCC patients are inefficient due to the lack of diagnostic and therapeutic markers. The expression of novel tumor-associated kinases has the potential to dramatically shape tumor cell behavior. Identifying tumor-associated kinases can lend insight into patterns of tumor growth and characteristics. In the present study, we investigated the receptor tyrosine kinase-like orphan receptor 2 (Ror2), a new tumor-associated kinase, in RCC primary tumors and cell lines. Knockdown of Ror2 expression in RCC cells with specific shRNA significantly More >

Ting Liu¹, Fang Liu¹, Lei-Wen Peng, Li Chang, Yong-Mei Jiang

Oncology Research, Vol.26, No.5, pp. 817-826, 2018, DOI:10.3727/096504017X15130753659625

Abstract Peritoneal macrophages (PMs) are the major cell type of peritoneal cells that participate in multiple aspects of innate and acquired immunity in the peritoneal cavity. PMs have an ability to release a large amount of proinflammatory and anti-inflammatory cytokines and therefore play a critical role in regulating the differentiation of innate immune cells and inflammatory T cells. Accumulating studies demonstrate that the immunological reactions and inflammatory responses of PMs are strongly related to the pathogenic processes of various inflammatory diseases and abdominal cancers. Consequently, the regulation of PM activation has gradually emerged as a promising More >

Jun-Jun Zhang^*, Dan-Dan Wang^*, Chen-Xiang Du^†, Yan Wang^‡

Oncology Research, Vol.26, No.3, pp. 345-352, 2018, DOI:10.3727/096504017X14953948675449

Abstract Cervical cancer is a common malignancy of the female reproductive system. Long noncoding RNAs (lncRNAs) have been reported to modulate tumor progression in multiple cancers. The lncRNA antisense noncoding RNA in the INK4 locus (ANRIL) has been identified as an oncogenic molecular target in several tumors; however, the function and underlying mechanism involved in cervical cancer oncogenesis are still unclear. In the present study, RT-PCR showed that ANRIL expression was significantly upregulated in cervical cancer tumors and cell lines. Nevertheless, ANRIL knockdown transfected with interference oligonucleotide inhibited the proliferation activity and invasive ability, and promoted More >

Jingyu Wang¹, Ping Jiang^1,*, Jianjun Qi²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1889-1918, 2024, DOI:10.32604/cmes.2024.049813

Abstract The unmanned aerial vehicle (UAV) swarm plays an increasingly important role in the modern battlefield, and the UAV swarm operational test is a vital means to validate the combat effectiveness of the UAV swarm. Due to the high cost and long duration of operational tests, it is essential to plan the test in advance. To solve the problem of planning UAV swarm operational test, this study considers the multi-stage feature of a UAV swarm mission, composed of launch, flight and combat stages, and proposes a method to find test plans that can maximize mission reliability.… More >