Keiko Yanagihara^1,*, Masato Yoshida², Kensaku Awaji², Tamami Yamakawa¹, Sena Kato¹, Miki Tamura¹, Koji Nagata³

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.073891 - 30 December 2025

Abstract Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have transformed the management of hormone receptor–positive/HER2–negative (HR+/HER2–) advanced breast cancer, yet evidence for elderly or poor-performance patients remains limited. This study examined real-world outcomes of palbociclib plus endocrine therapy in Asian patients, with additional subgroup analyses by age and performance status. Methods: We retrospectively analyzed 46 consecutive Asian patients with recurrent or de novo HR+/HER2− breast cancer treated with first-line palbociclib plus ET between April 2021 and March 2025. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall response rate (ORR), disease control rate (DCR), and safety.… More >

Yimin Liu^1,#, Bin Liu^2,3,4,#, Huabin Gao¹, Jinlong Wang⁵, Jingya Duan¹, Xiaolan Huang¹, Yuexi Liu¹, Ying Huang¹, Wenjing Liao¹, Ruonan Li^1,*, Hua Linghu^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069007 - 30 December 2025

Abstract Objectives: High-grade serous ovarian cancer (HGSOC), the most common subtype of epithelial ovarian cancer (EOC), exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis. Human epididymis protein 4 (HE4), a key diagnostic biomarker for ovarian cancer, is involved in fibrotic processes in several non-malignant diseases. Given the clinical significance of stromal fibrosis in HGSOC and the potential link between HE4 and fibrosis, this study aimed to investigate the role of HE4 in the formation of stromal fibrosis in HGSOC. Methods: A total of 126 patients with gynecological conditions were included and divided into… More > Graphic Abstract

Ashok Kumar Sah^1,*, Ranjay Kumar Choudhary^1,2, Velilyaeva Alie Sabrievna³, Karomatov Inomdzhon Dzhuraevich⁴, Anass M. Abbas⁵, Manar G. Shalabi⁵, Nadeem Ahmad Siddique⁶, Raji Rubayyi Alshammari⁷, Navjyot Trivedi⁸, Rabab H. Elshaikh¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068238 - 30 December 2025

Abstract Male breast cancer (MBC) is rare, representing 0.5%–1% of all breast cancers, but its incidence is increasing due to improved diagnostics and awareness. MBC typically presents in older men, is human epidermal growth factor receptor 2 (HER2)-negative and estrogen receptor (ER)-positive, and lacks routine screening, leading to delayed diagnosis and advanced disease. Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations. Clinically, it may resemble gynecomastia but usually appears as a unilateral, painless mass or nipple discharge. Advances in imaging and liquid biopsy have More >

Mingming Huang¹, Yunfan Ye^1,*, Zhiping Cai²

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-17, 2026, DOI:10.32604/cmc.2025.072399 - 09 December 2025

Abstract As a fundamental component in computer vision, edges can be categorized into four types based on discontinuities in reflectance, illumination, surface normal, or depth. While deep CNNs have significantly advanced generic edge detection, real-time multi-class semantic edge detection under resource constraints remains challenging. To address this, we propose a lightweight framework based on PiDiNet that enables fine-grained semantic edge detection. Our model simultaneously predicts background and four edge categories from full-resolution inputs, balancing accuracy and efficiency. Key contributions include: a multi-channel output structure expanding binary edge prediction to five classes, supported by a deep supervision More >

Yuri A. Piven¹, Danila V. Sorokin², Nastassia A. Varabyeva¹, Alexandra L. Mikhaylova², Fedor B. Bogdanov², Elena V. Shafranovskaya¹, Raman M. Puzanau³, Fedor A. Lakhvich¹, Alexander M. Scherbakov^2,4,*

Oncology Research, Vol.33, No.12, pp. 4049-4072, 2025, DOI:10.32604/or.2025.067832 - 27 November 2025

Abstract Background: The most aggressive forms of breast cancer are characterized by independence from steroid hormones but a strong dependence on growth factors. In such cancer cells, oncogenic receptors, including human epidermal growth factor receptor 2 (HER2), are activated, and their targeted inhibition represents an attractive therapeutic strategy. The study aimed to develop small-molecule potential dual heat shock protein 90 (HSP90)-HER2 inhibitors and evaluate them as anticancer agents in HER2-positive cells. Methods: The research project involved obtaining a series of compounds with potential dual inhibitory activity against HSP90 and HER2 by targeted organic synthesis, which was… More > Graphic Abstract

Abdulbari Bener^1,2,*, Ünsal Veli Üstündağ³, Emir Barışık⁴, Cem Cahit Barışık⁵

Canadian Journal of Urology, Vol.32, No.5, pp. 401-409, 2025, DOI:10.32604/cju.2025.067184 - 30 October 2025

Abstract Objectives: The evidence remains insufficient and controversial for evaluating modifiable parameters—such as vitamin D, calcium, ferritin, and uric acid—as preclinical biomarkers to contribute to the prevention and early diagnosis of prostate cancer, a disease with a prevalence of up to 10%–20% in men over 50 and strongly associated with environmental factors including diet (high in fat and red meat), obesity, physical inactivity, and carcinogen exposure. This study aims to investigate the potential biomarker role of vitamin D, calcium, ferritin, and uric acids in reducing the risk of prostate cancer (PCa). Methods: The case-control design was… More >

Ellen M. Cahill, Ankur U. Choksi, Sharath S. Reddy, Dylan C. H. Heckscher, Katherine Rotker, Stanton C. Honig^*

Canadian Journal of Urology, Vol.32, No.5, pp. 521-527, 2025, DOI:10.32604/cju.2025.064559 - 30 October 2025

Abstract Introduction: Spermatocelectomy is a surgical procedure performed for symptomatic spermatoceles. Published data is limited with respect to recurrence rates, complication rates, and patient satisfaction. The core concept of spermatocelectomy is to identify the communication between epididymis and spermatocele, which can be difficult and may result in spermatocele recurrence. We postulate that a combined spermatocelectomy with epididymectomy will yield a lower rate of recurrence. Methods: A retrospective chart review of patients with symptomatic spermatoceles undergoing spermatocelectomy with or without epididymectomy at our institution was performed. Patients were excluded from epididymectomy if they were interested in fertility… More >

Yi Yan^1,2,#, Min He^1,2,#, Feifeng Mao³, Xinyu Zhang⁴, Liyu Wang⁵, Jingwei Li^1,2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 3003-3021, 2025, DOI:10.32604/phyton.2025.069166 - 29 October 2025

Abstract Houttuynia cordata, a characteristic edible and medicinal plant in southwestern China, is prone to absorbing lead (Pb²⁺). Excessive consumption may lead to Pb²⁺ accumulation in the human body, which has been linked to serious health risks such as neurotoxicity, kidney damage, anemia, and developmental disorders, particularly in children. Therefore, the development of molecular markers associated with Pb²⁺ uptake and the investigation of the plant’s physiological responses to Pb²⁺ pollution are of great significance. In this study, 72 H. cordata germplasms were evaluated for Pb²⁺ accumulation after exogenous Pb²⁺ treatment. A significant variation in Pb²⁺ content was observed among the germplasms, indicating… More >

Yifei Wang, Xiaoxiao Han^*, Miaomiao Yuan, Yangguang Zhao, Wei Zhu, Feng Chen

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.2, pp. 1-1, 2025, DOI:10.32604/icces.2025.012585

Abstract With the advancement of the personalised medicine industry, multi-material targeted drug delivery systems have garnered significant attention due to the higher drug bioavailability and synergistic effects of combined drug therapies. However, the fabrication throughput of such systems often fails to satisfy the demands of clinical applications. Volumetric printing, distinguished by its remarkable capability for rapid fabrication, presents a promising approach for fabricating these systems. Nevertheless, during volumetric printing, formed parts are prone to displacement relative to their intended locations due to variations in ink density, viscosity, and other factors, resulting in geometric distortion and complicating… More >

Yuanyuan Yang^1,2,#, Peipei Zhao^1,2,#, Hepu Chen^1,3, Yixuan Tu⁴, Yujia Zhou², Xu Liu³, Lyly Sreang³, Zhigang Zhou^3,5,*, Jian Tu^1,2,*

Oncology Research, Vol.33, No.11, pp. 3247-3268, 2025, DOI:10.32604/or.2025.066440 - 22 October 2025

Abstract Hepatocellular carcinoma (HCC) is characterized by its highly invasive and metastatic potential, as well as a propensity for recurrence, contributing to treatment failure and increased mortality. Under physiological conditions, the liver maintains a balance in lipid biosynthesis, degradation, storage, and transport. HCC exhibits dysregulated lipid metabolism, driving tumor progression and therapeutic resistance. This review aims to elucidate the roles of fatty acid, sphingolipid, and cholesterol metabolism in HCC pathogenesis and explore emerging therapeutic strategies targeting these pathways. Key findings demonstrate that upregulated enzymes like fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), enhance de novo lipogenesis and… More >