Yufeng Liu*, Zhengliang Cheng†, Feng Pan‡, Weigang Yan§
Oncology Research, Vol.25, No.6, pp. 989-999, 2017, DOI:10.3727/096504016X14813867762123
Abstract Spinal osteosarcoma (OS) has been proven to be more difficult to treat owing to potently malignant metastasis.
The present study aimed to explore the functional role of microRNA (miR)-373 in cell growth and invasion
of OS cells, as well as its underlying mechanism. The expression of miR-373 was analyzed in spinal OS tissues and cell lines. MG-63 cells were transfected with the miR-373 mimic or inhibitor and/or treated with the
phosphoinositide 3-kinase (PI3K) (LY294002) inhibitor or Ras-related C3 botulinum toxin substrate 1 (Rac)
guanosine triphosphate (GTPase) (NSC23766) inhibitor, and then the impact of miR-373 aberrant… More >
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