Catalina Vargas-Acevedo¹, Gareth J. Morgan¹, Rhynn Soderstrom², Richard Ing³, Nicholas Houska³, Jenny E. Zablah^1,*

Congenital Heart Disease, Vol.19, No.4, pp. 389-397, 2024, DOI:10.32604/chd.2024.055121 - 31 October 2024

Abstract Introduction: Pulmonary hemorrhage (PHm) is a life-threatening complication that can occur after catheter-based interventions in patients with pulmonary vein stenosis (PVS). Inhaled racemic epinephrine (iRE) and tranexamic acid (iTXA) have been used in other conditions, but a standardized approach in PVS has not been described. We aimed to describe the current management of PHm after PVS catheter-based interventions. Methods: We present a retrospective review of episodes of PHm from July 2022 to February 2024. PHm was defined as frank blood suctioned from the endotracheal tube including blood-tinged secretions and >3% decrease in saturations and/or ventilatory… More >

Qianbing Tan^1,*, Jin Wang¹, Yisen Liu¹, Guangyu Sun¹, Huijing Gao¹, Yong Peng¹, Song Yao¹, Kui Wang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.011212

Abstract Bio-inspired thin-walled structures have attracted widespread attention in the engineering field due to their excellent energy absorption capacity. In this work, it was observed that the stem of the bird-of-paradise plant consisted of longitudinal thin walls and transverse diaphragms. The diaphragms inside of the stems are parallel to each other within a column and exhibit staggered arrangements in the adjacent columns. Inspired by the stem of the bird-of-paradise plant, the staggered diaphragm design was introduced to improve the compressive properties of structures. Considering the staggered arrangement method and the Centro symmetry method, three types of… More >

WENJUAN ZHU¹, ZHENGZHENG JU², FAN CUI^2,*

BIOCELL, Vol.48, No.9, pp. 1379-1388, 2024, DOI:10.32604/biocell.2024.052205 - 04 September 2024

Abstract Objective: Diabetic nephropathy (DN) is a deleterious microangiopathy of diabetes, constituting a critical determinant of fatality in diabetic patients. This work is purposed to disclose the effects and modulatory mechanism of BTG anti-proliferation factor 2 (BTG2) during the pathological process of DN. Methods: BTG2 expression in kidney tissues of diabetic mice and high glucose (HG)-exposed human proximal tubular cell line HK-2 was assessed with Western blot and RT-qPCR. The diabetic mice model was constructed by streptozotocin injection and confirmed by the blood glucose level beyond 16.7 mmol/L. Hematoxylin and eosin (H&E) staining and measurement of… More >

Mengxu Su¹, Zhanjiang Han^1,*, Zhen Zhao², Xiaofeng Wu¹, Jiaju Wu¹

Phyton-International Journal of Experimental Botany, Vol.93, No.7, pp. 1689-1703, 2024, DOI:10.32604/phyton.2024.052814 - 30 July 2024

Abstract Leaves are important ‘source’ organs that synthesize organic matter, providing carbon sources for plant growth. Here, we used Populus talassica × Populus euphratica, the dominant species in ecological and timber forests, to simulate carbon limitation through artificial 25%, 50%, and 75% defoliation treatments and explore the effects on root, stem, and leaf morphology, biomass accumulation, and carbon allocation strategies. At the 60th d after treatment, under 25% defoliation treatment, the plant height, specific leaf weight, root surface area and volume, and concentrations of non-structural carbohydrates in stem and root were significantly increased by 9.13%, 20.00%, 16.60%,… More >

JIANHONG LIU^1,#, KAI HE^2,#, HAN WANG^3,#, XIAOHONG CHENG^1,*

BIOCELL, Vol.48, No.1, pp. 21-32, 2024, DOI:10.32604/biocell.2023.045631 - 30 January 2024

Abstract Exosomes, nanoscale extracellular vesicles (EVs) derived from the invagination of the endosomal membrane, are secreted by a majority of cell types. As carriers of DNA, mRNA, proteins, and microRNAs, exosomes are implicated in regulating biological activities under physiological and pathological conditions. Kidney-derived exosomes, which vary in origin and function, may either contribute to the pathogenesis of disease or represent a potential therapeutic resource. Membranous nephropathy (MN), an autoimmune kidney disease characterized by glomerular damage, is a predominant cause of nephrotic syndrome. Notably, MN, especially idiopathic membranous nephropathy (IMN), often results in end-stage renal disease (ESRD),… More > Graphic Abstract

WEI LU^1,*, KAN GUO², DIANMEI XI¹, ZHAOXIA XIA¹

BIOCELL, Vol.47, No.9, pp. 1995-2008, 2023, DOI:10.32604/biocell.2023.024591 - 28 September 2023

Abstract Background: Mesenchymal stem cell (MSC)-derived exosomes are closely related to pyroptosis in diabetic nephropathy (DN). This study aimed to explore the protective effect of exosomal miR-30a-5p on podocyte pyroptosis in DN. Methods: Streptozotocin was used to establish the mouse model of DN. Human bone marrow MSC-derived exosomes were extracted and identified via transmission electron microscopy, nanoparticle tracking analysis, and western blotting. MiR-30a-5p mimics and non-control (NC) mimics were transfected into MSCs and podocytes, and exosomes were isolated from the MSCs. High glucose (HG)-induced podocyte model was established to determine the effect of exosomal miR-30a-5p on pyroptosis… More >

HANY M. ABD EL-LATEEF^1,2,*, SAFA H. QAHL³, EMAN FAYAD⁴, SARAH A. ALTALHI⁴, IBRAHIM JAFRI⁴, EL SHAIMAA SHABANA⁵, MARWA K. DARWISH^6,7, REHAB MAHER⁸, SAAD SHAABAN^1,9, SHADY G. EL-SAWAH^10,*

BIOCELL, Vol.47, No.8, pp. 1885-1895, 2023, DOI:10.32604/biocell.2023.030680 - 28 August 2023

Abstract Background: The increasing occurrence of diabetes mellitus (DM) noted worldwide has considerably elicited concern in the recent past. DM is associated with elevated vascular complications, morbidity, mortality, and poor quality of life. In this context, mesenchymal stem cells (MSCs) have shown significant therapeutic potentialities in managing and curing type 1 DM owing to their self-renewable, immunosuppressive, and differentiation capacities. We investigated the potential action of N, N′-diphenyl-1,4-phenylenediamine (DPPD), a well-known synthetic antioxidant to enhance the therapeutic ability of the adipose-derived stem cells (AD-MSCs) in alleviating kidney and liver complications in diabetic rats. Methods: Over the… More > Graphic Abstract

FENGMEI QIAN^1,2, PEIYAO REN², LI ZHAO², DANNA ZHENG², WENFANG HE³, JUAN JIN^3,*

BIOCELL, Vol.47, No.8, pp. 1853-1867, 2023, DOI:10.32604/biocell.2023.029353 - 28 August 2023

Abstract Background: Diabetic nephropathy (DN) is a serious complication of diabetes with rising prevalence worldwide. We aimed to explore the anti-DN mechanisms of the compound celastrol derived from the medicinal plant Tripterygium wilfordii. Methods: Celastrol-related targets were obtained from Herbal Ingredients’ Targets (HIT) and GeneCards databases. DN-related targets were retrieved from GeneCards, DisGeNET, and Therapeutic Targets Database (TTD). A Protein-protein interaction (PPI) network was established using the Search Tool for the Retrieval of Interacting Genes (STRING) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using ClusterProfiler. The cytoHubba plugin… More > Graphic Abstract

WEI LIANG^1,2,*, ZONGWEI ZHANG^1,2, KEJU YANG^1,2,3, HONGTU HU^1,2, QIANG LUO^1,2, ANKANG YANG^1,2, LI CHANG⁴, YUANYUAN ZENG⁴

BIOCELL, Vol.47, No.6, pp. 1253-1263, 2023, DOI:10.32604/biocell.2023.027373 - 19 May 2023

Abstract Background: Diabetic nephropathy (DN) is the most common complication of type 2 diabetes mellitus and the main cause of end-stage renal disease worldwide. Diagnostic biomarkers may allow early diagnosis and treatment of DN to reduce the prevalence and delay the development of DN. Kidney biopsy is the gold standard for diagnosing DN; however, its invasive character is its primary limitation. The machine learning approach provides a non-invasive and specific criterion for diagnosing DN, although traditional machine learning algorithms need to be improved to enhance diagnostic performance. Methods: We applied high-throughput RNA sequencing to obtain the genes… More >

Caihui Lan¹, Haifeng Li^2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.3, pp. 2985-3010, 2023, DOI:10.32604/cmes.2023.026321 - 09 March 2023

Abstract Sharing of personal health records (PHR) in cloud computing is an essential functionality in the healthcare system. However, how to securely, efficiently and flexibly share PHRs data of the patient in a multi-receiver setting has not been well addressed. For instance, since the trust domain of the cloud server is not identical to the data owner or data user, the semi-trust cloud service provider may intentionally destroy or tamper shared PHRs data of user or only transform partial ciphertext of the shared PHRs or even return wrong computation results to save its storage and computation… More >