Hexin Yue¹, Cian Vyas^1,2,*, Paulo Bartolo^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.011598

Abstract Peripheral nerve injury can result in significant motor or sensory impairment. Traditional treatments have certain drawbacks and often result in suboptimal clinical results. To overcome these limitations, tissue engineering and bioprinting technologies are promising approaches for manufacturing nerve guidance conduits (NGCs). NGCs are tubular biostructures that bridge the nerve injury site, provide an appropriate microenvironment, and promote peripheral nerve regeneration by guiding axonal growth. The architecture of NGCs needs to mimic the morphology of natural peripheral nerves by designing their topology to regulate nerve cell behaviours. Topographic guidance cues are an effective element in improving… More >

Hongyu Zhou¹, Hortense Le Ferrand^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.010990

Abstract 4D printing enables 3D-printed structures to morph upon being exposed to external stimuli. Amongst all engineering materials, polymers show high 3D printability as well as tunability regarding to its morphing behaviour and functionalities. Generally, composites with epoxy as matrix shows high modulus and strength, whereas its mechanically brittle property makes it difficult to be morphed and snapped-through at room temperature, thereby limiting its 4D printability and its functionality. On the other, Polydimethylsiloxane (PDMS), as an elastomer, shows its high elasticity and stretchability, yet its printability and mechanical properties of its printed composites still need improving… More >

Hamidreza Noori¹, Bohayra Mortazavi^{2, 3}, Alessandro Di Pierro⁴, Emad Jomehzadeh⁵, Xiaoying Zhuang^{2, 3}, Zi Goangseup⁶, Kim Sang-Hyun⁷, Timon Rabczuk^{8, 9, *}

CMC-Computers, Materials & Continua, Vol.65, No.3, pp. 2009-2032, 2020, DOI:10.32604/cmc.2020.011256 - 16 September 2020

Abstract In modern physics and fabrication technology, simulation of projectile and target collision is vital to improve design in some critical applications, like; bulletproofing and medical applications. Graphene, the most prominent member of two dimensional materials presents ultrahigh tensile strength and stiffness. Moreover, polydimethylsiloxane (PDMS) is one of the most important elastomeric materials with a high extensive application area, ranging from medical, fabric, and interface material. In this work we considered graphene/PDMS structures to explore the bullet resistance of resulting nanocomposites. To this aim, extensive molecular dynamic simulations were carried out to identify the penetration of… More >

Tianliang Qin¹, Libin Zhao^2,3,*, Jifeng Xu¹, Fengrui Liu^2,3,4, Jianyu Zhang⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.1, pp. 157-176, 2019, DOI:10.31614/cmes.2019.04379

Abstract Progressive damage models (PDMs) have been increasingly used to simulate the failure process of composite material structures. To accurately simulate the damage in each ply, 3D PDMs of composite materials have received more attention recently. A characteristic element length (CEL), which is an important dimensional parameter of PDMs for composite materials, is quite difficult to obtain for 3D elements, especially considering the crack directions during damage propagation. In this paper, CEL models for 3D elements in PDMs of unidirectional composite structures are presented, and their approximate formulae are deduced. The damage in unidirectional composite materials… More >

E. P. Yalcintas¹, J. Hu¹, Y. Liu^1,2, A. Voloshin^1,2,3

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.2, pp. 151-180, 2014, DOI:10.3970/cmes.2014.098.151

Abstract Mechanical behavior of cells plays a crucial role in response to external stimuli and environment. It is very important to elucidate the mechanisms of cellular activities like spreading and alignment as it would shed light on further biological concepts. In this study, a multi-scale computational approach is adopted by modeling the cytoskeleton of cell as a tensegrity structure. The model is based on the complementary force balance between the tension and compression elements, resembling the internal structure of cell cytoskeleton composed of microtubules and actin filaments. The effect of surface topology on strain energy of… More >

Christopher A. Lemmon^1,2, Nathan J. Sniadecki³, Sami Alom Ruiz^1,3, John L. Tan, Lewis H. Romer^2,4,5, Christopher S. Chen^3,4

Molecular & Cellular Biomechanics, Vol.2, No.1, pp. 1-16, 2005, DOI:10.3970/mcb.2005.002.001

Abstract The interplay of mechanical forces between the extracellular environment and the cytoskeleton drives development, repair, and senescence in many tissues. Quantitative definition of these forces is a vital step in understanding cellular mechanosensing. Microfabricated post array detectors (mPADs) provide direct measurements of cell-generated forces during cell adhesion to extracellular matrix. A new approach to mPAD post labeling, volumetric imaging, and an analysis of post bending mechanics determined that cells apply shear forces and not point moments at the matrix interface. In addition, these forces could be accurately resolved from post deflections by using images of More >