Yan Zhen*1, Dongming Li*†1, Wen Li*, Weimin Yao*†1, Aibing Wu‡, Jing Huang‡, Hongli Gu*†, Yujie Huang*†, Yajun Wang*, Jun Wu*†, Min Chen*†, Dong Wu*†, Quanchao Lyu*, Weiyi Fang§, Bin Wu*†
Oncology Research, Vol.23, No.1-2, pp. 61-68, 2015, DOI:10.3727/096504015X14478843952861
Abstract It is largely recognized that PDCD4 is frequently lost in tumors of various origins, including lung cancer, and
its loss contributes to tumor progression. However, its role and molecular mechanism remain largely unexplored in non-small cell lung cancer (NSCLC). In this study, downregulated PDCD4 mRNA expression was
found in NSCLC tissues compared to their corresponding paracarcinoma tissues and distal paracarcinoma tissues. Induced expression of PDCD4 inhibited cell growth and proliferation and cell cycle transition in vitro.
Conversely, knocking down PDCD4 expression promoted cell growth and proliferation. Mechanistically,
PDCD4 inactivated PI3K/Akt signaling and its downstream cell More >
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