Yangjing Chen, Ruimin Zhao, Qian Zhao, Yuan Shao, Shaoqiang Zhang

Oncology Research, Vol.24, No.3, pp. 153-160, 2016, DOI:10.3727/096504016X14612603423476

Abstract Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) is a corepressor for the transcription factor PBX. Previous studies showed that HPIP is frequently overexpressed in many tumors. However, the role of HPIP in head-and-neck squamous cell carcinoma (HNSCC) has not yet been determined. Thus, we decided to investigate the effects and mechanisms of HPIP in HNSCC. Our results demonstrated that HPIP is highly expressed in human HNSCC cell lines and provides the first evidence that knockdown of HPIP obviously inhibits proliferation and migration/invasion in HNSCC cells in vitro, as well as inhibits tumor growth in More >

Dagang Li^*, Huizong Li^†, Yuping Yang^*, Le Kang^*

Oncology Research, Vol.26, No.4, pp. 537-546, 2018, DOI:10.3727/096504017X15009792179602

Abstract Long noncoding RNA urothelial carcinoma-associated 1 (lncRNA UCA1) has gained more attention in recent years due to its oncogenic roles in various cancers. MicroRNA-144 (miR-144) participates in the regulation of the growth of many cancer cells. This study investigated the interaction between lncRNA UCA1 and miR-144 in lung cancer cells. The potential downstream protein of miR-144 was also assessed. Our results found that lncRNA UCA1 was highly expressed in human lung cancer A549, H517, H4006, H1299, and H1650 cells compared to normal embryonic lung WI-38 and HEL-1 cells. Knockdown of lncRNA UCA1 significantly inhibited lung More >

Ge Kang^1,*, Qiumeng Ouyang¹, Pengwan Chen¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.010508

Abstract It is of great significance to study the dynamic mechanical response of explosive charge to ensure the safety and reliability of weapon system. The manifold method is a novel numerical theory proposed in recent years to simulate the static and dynamic mechanical behavior of solid material. In the present work, a threedimensional numerical manifold software (3D-NMM) based on continuous-discontinuous coupled theory is developed to solve the impact response of PBX. Firstly, based on the 3D finite element topology, a four-node tetrahedral coverage system is established, and the shape function and displacement function, element stiffness matrix… More >

Xiaoliang Deng^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.010001

Abstract Polymer bonded explosives (PBXs) are one of typical heterogeneous materials comprised of solid energetic particles surrounded by a polymer binder. PBXs are widely encountered in various applications such as rocket propellants and main explosive charges. PBXs can ignite or detonate due to an accidental impact loading, which usually leads to serious losses to personnel and property. Therefore, safety of PBXs regarding to various loading conditions is of great concern.
The ignition of PBXs due to impact is a mechanical-thermal-chemical coupled phenomenon. The evolutions of micro-cracks and other damage behaviors are essential to help understanding of… More >

Zhongbin Zhou, Pengwan Chen, Fenglei Huang

The International Conference on Computational & Experimental Engineering and Sciences, Vol.17, No.4, pp. 125-126, 2011, DOI:10.3970/icces.2011.017.125

Abstract The macroscopic deformation and fracture behavior of a polymer bonded explosive (PBX) simulation material were studied by using Digital Image Correlation (DIC) method. The Brazilian test, semi-circular bending test, punch loading and uniaxial loading experiments were chosen for the study. The whole displacement and strain fields were obtained by using DIC method at macro-scale. New sights into fracture processes and failure mechanisms of simulant samples under different quasi-static loading conditions have been obtained. Macro studies show that the experimental results are in agreement with the theoretical analysis. The experimental methods combined with DIC technique have More >