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    ARTICLE

    Construction of the panoptosis-related gene model and characterization of tumor microenvironment infiltration in hepatocellular carcinoma

    XINRUI SHI1, XIA GAO1, WENCONG LIU2, XUEJIAO TANG1, JIAYI LIU1, DONGCHEN PAN1, XUEQING DUAN1, YUQING JIN1, WEIYAN REN1, LEI YANG1,*, WENXUAN LIU1,*

    Oncology Research, Vol.31, No.4, pp. 569-590, 2023, DOI:10.32604/or.2023.028964 - 25 June 2023

    Abstract Hepatocellular carcinoma (HCC) is the most common fatal cancer worldwide, patients with HCC have a high mortality rate and poor prognosis. PANoptosis is a novel discovery of programmed cell death associated with cancer development. However, the role of PANoptosis in HCC remains obscure. In this study, we enrolled 274 PANoptosisrelated genes (PANRGs) and screened 8 genes to set up a prognostic model. A previous scoring system calculated PANscore was utilized to quantify the individual risk level of each HCC patient, and the reliability of the prognostic model has been validated in an external cohort. Nomogram More >

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