Hai-tao Geng^*, Rui-juan Cao^*, Lei Cheng^†, Chun-yuan Liu^†

Oncology Research, Vol.25, No.7, pp. 1039-1046, 2017, DOI:10.3727/096504016X14813914187138

Abstract Hepatocyte cell adhesion molecule (hepaCAM), a new type of CAM, belongs to the immunoglobulin superfamily. Recently, hepaCAM was reported to be implicated in cancer development, and many researchers investigated its biological function in the tumorigenesis of various cancers. However, what kind of role hepaCAM plays in colorectal cancer (CRC) remains unknown. In this study, we found that hepaCAM was downregulated in CRC tissues and cell lines. Overexpression of hepaCAM inhibited CRC cell proliferation, migration, and invasion in vitro. Furthermore, the tumorigenesis assay showed that increased expression of hepaCAM suppressed CRC tumor growth and metastasis in More >

Yi Sun^1,2,*, Chihua Lu^1,2, Zhien Liu^1,2, Menglei Sun¹, Hao Chen¹

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.3, pp. 2307-2330, 2023, DOI:10.32604/cmes.2023.025313

Abstract In automotive industries, panel acoustic contribution analysis (PACA) is used to investigate the contributions of the body panels to the acoustic pressure at a certain point of interest. Currently, PACA is implemented mostly by either experiment-based methods or traditional numerical methods. However, these schemes are effort-consuming and inefficient in solving engineering problems, thereby restraining the further development of PACA in automotive acoustics. In this work, we propose a PACA scheme using discontinuous isogeometric boundary element method (IGABEM) to build an easily implementable and efficient method to identify the relative acoustic contributions of each automotive body… More >