Teng Liu*, Juan Xu†, Hong Li Yan‡, Feng Chun Cheng*, Xi Jie Liu*
Oncology Research, Vol.27, No.7, pp. 773-778, 2019, DOI:10.3727/096504018X15208986577685
Abstract Luteolin, which is found in plant foods, has a range of therapeutic applications. In order to examine the potential roles of luteolin in ovarian teratocarcinoma, the human ovarian teratocarcinoma cell line PA-1 was selected
for functional experiments in vitro and in vivo. We demonstrated that luteolin inhibited the proliferation and
colony formation of PA-1 cells in vitro. The flow cytometry results suggested that luteolin induced apoptosis
of PA-1 cells in a dose-dependent manner. Immunofluorescence and qRT-PCR results showed that the expression of B-cell lymphoma-2 (Bcl-2) was decreased in luteolin-treated cells, whereas the expression of Bcl-2-
associated X (Bax) was increased… More >
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