Xiaohe Guo*, Lanfang Zhang*, Yingying Fan*, Dezhong Zhang†, Lei Qin*, Shuping Dong*, Guangyan Li*
Oncology Research, Vol.25, No.5, pp. 799-808, 2017, DOI:10.3727/096504016X14783691306605
Abstract Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. Oxysterol-binding proteinrelated protein 8 (ORP8) functions as a sterol sensor that regulates a number of cellular functions. We showed
that ORP8 expression was significantly lower in GC tissues and cells. Overexpression of ORP8 significantly
inhibited GC cell proliferation in several GC cells. The formation of colonies in AGS cells was inhibited by the
overexpression of ORP8. Moreover, overexpression of ORP8 significantly decreased implanted tumor growth
in nude mice. Overexpression of ORP8 resulted in a significant increase in CHOP and GRP78 expression and
the… More >
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