YAO QIAN2, JINGPING WANG2, ZIWAN JI2, HAO CHEN2, YUCANG HE2, XULING LV2, ZIKAI ZHANG2, TIAN LI2, TIANYUN PAN3, LIQUN LI2, MING LIN1,*
BIOCELL, Vol.45, No.1, pp. 189-198, 2021, DOI:10.32604/biocell.2021.011827
- 26 January 2021
Abstract The cell activity of adipose-derived stem cells (ADSCs) is affected by the intracellular reactive oxygen species
(ROS) and the level of autophagy. Previous studies reveal that acetyl-L-carnitine (ALC) possesses capacities of resisting
oxidative stress and regulating autophagy. Activating molecule in Beclin1-regulated autophagy protein 1 (AMBRA1)
plays a key role in initiating Beclin1-regulated autophagy. In the present study, we discovered ALC pretreatment (1
mM, 24 h) significantly increased the activity of ADSCs exposed to H2O2 (100 μM, 2 h) in vitro with improved
stemness, and reduced the production of intracellular ROS. In addition, we found for the More >
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