Jing Zhang^1,#, Huifen Qiao^1,#, Shenglong Wang^1,#, Jiawei Yuan¹, Qingsong Ba¹, Gensheng Zhang^1,2,*, Guiping Li^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2701-2718, 2025, DOI:10.32604/phyton.2025.070017 - 30 September 2025

Abstract Wheat stripe rust, a devastating disease caused by the fungal pathogen Puccinia striiformis f. sp. tritici (Pst), poses a significant threat to global wheat production. Growing resistant cultivars is a crucial strategy for wheat stripe rust management. However, the underlying molecular mechanisms of wheat resistance to Pst remain incompletely understood. To unravel these mechanisms, we employed high-throughput RNA sequencing (RNA-Seq) to analyze the transcriptome of the resistant wheat cultivar Mianmai 46 (MM46) at different time points (24, 48, and 96 h) post-inoculation with the Pst race CYR33. The analysis revealed that Pst infection significantly altered the expression of genes… More >

Hafiza Muniba Din Muhammad¹, Safina Naz¹, Zarina Bibi², Mohamed A. A. Ahmed³, Alina-Stefania Stanciu⁴, Riaz Ahmad^5,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2631-2648, 2025, DOI:10.32604/phyton.2025.069474 - 30 September 2025

Abstract The production of crops is badly affected by climate change globally. Mitigation of adverse effects of climate change is in need of time through different management practices such as developing tolerant genetic resources, hormonal applications to boost defense systems, nanoparticles, and balanced fertilization. The nano-hormonal synergy had the potential to mitigate the adverse effects of climate change by modulation of morpho-physiological and biochemical activities. Plant growth, yield, and quality can be enhanced with the supplementation of nano-hormonal interactions. Therefore, the current study explores the synergy between nanoparticles and phytohormonal use. The nanoparticles, even in low… More >

Livanshee Gupta¹, Nouha Haoudi^2,3,*, Lanjelina Oinam¹, Ananya Mahajan¹, Sonia Morya^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.9, pp. 2669-2700, 2025, DOI:10.32604/phyton.2025.065058 - 30 September 2025

Abstract The trends of consuming or using eco-friendly, biodegradable products due to the change in the lifestyle of the people have led to the exploration of new sources from plants or animals. Seed mucilage (SeM) is an underexplored component of plants that can be brought into play to deal with such problems. Mucilage, a viscous polysaccharide that can be obtained when seeds like chia, flax, garden cress, and tomato get hydrated and form a slimy, gel-like substance around the seed coat, can be utilized due to its unique characteristics. It has been used in developing many… More >

Anjali Kariyarath Valappil^1,#, Reshmi Akter^2,#, Muhammad Awais², Dong Uk Yang³, Daehyo Jung², Li Ling⁴, Eun Kim⁵, Kyu Hyeong Yoon⁵, Yoon Ok Lee⁵, Deok Chun Yang^1,2,4,*

BIOCELL, Vol.49, No.9, pp. 1771-1795, 2025, DOI:10.32604/biocell.2025.069145 - 25 September 2025

Abstract Objectives: The phytochemical investigation of traditional herbal medicines holds significant promise for modern drug discovery, particularly in cancer therapy. This study aimed to evaluate the cytotoxicity, apoptosis induction, and immune-modulatory activities of extracts from three herbal medicines with historical use in traditional medicine—Acanthopanax sessiliflorus, Phragmites communis, and Pinus densiflora, as well as their combined extract (GMAS 01/COM), on human lung cancer cells (A549) and normal cell lines, including murine macrophages (RAW 264.7) and human keratinocytes (HaCaT). Methods: Plant extracts were prepared using aqueous extraction, sonication, and rotary evaporation. The total phenolic and flavonoid contents were quantified using the… More >

Zoran S. Ilić^1,*, Ljiljana Stanojević², Lidija Milenković¹, Ljubomir Šunić¹, Dragana Lalević¹, Aleksandra Milenković², Žarko Kevrešan³

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2515-2527, 2025, DOI:10.32604/phyton.2025.069082 - 29 August 2025

Abstract This study aims to determine the phytochemical composition and antioxidant activity (AA) of different plant parts (bulbs, stalk, leaves and flowers) of wild rosy garlic (Allium roseum) from Montenegro. The flower exhibited the highest concentration of total phenols (55.7 GAE/g d.e.), followed by the leaf (25.6 mg GAE/g d.e.). The leaf displayed the highest concentration of total flavonoids (41.48 mg RE/g d.e.), followed by the flower (36.26 mg RE/g d.e.) and top part of the stalk (26.80 mg RE/g d.e.). The AA of different parts of A. roseum after 60 min of incubation decreased in the following… More >

Alejandra Sánchez-Reyna¹, Yolanda González-García², Ángel Gabriel Alpuche-Solís³, Gregorio Cadenas-Pliego⁴, Adalberto Benavides-Mendoza^5,6, Antonio Juárez-Maldonado^6,7,*

Phyton-International Journal of Experimental Botany, Vol.94, No.7, pp. 2097-2116, 2025, DOI:10.32604/phyton.2025.067092 - 31 July 2025

Abstract Tomato is an economically important crop that is susceptible to biotic and abiotic stresses, situations that negatively affect the crop cycle. Biotic stress is caused by phytopathogens such as Fusarium oxysporum f. sp. lycopersici (FOL), responsible for vascular wilt, a disease that causes economic losses of up to 100% in crops of interest. Nanomaterials represent an area of opportunity for pathogen control through stimulations that modify the plant development program, achieving greater adaptation and tolerance to stress. The aim of this study was to evaluate the antimicrobial capacity of the nanoparticles and the concentrations used in tomato… More >

Bismillah Mubeen^1,2,#, Ammarah Hasnain^2,3,#,*, Syed Atif Hasan Naqvi⁴, Fahad Hakim⁵, Syed Sheharyar Hassan Naqvi⁶, Muhammad Zeeshan Hassan⁴, Muhammad Umer Iqbal⁷, Mahmoud Moustafa⁸, Mohammed O. Alshaharni⁸, Mingzheng Duan^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.7, pp. 1941-1971, 2025, DOI:10.32604/phyton.2025.064056 - 31 July 2025

Abstract Plants have long served as a cornerstone for drug discovery, offering a vast repertoire of bioactive compounds with proven efficacy in combating oxidative stress, a pivotal driver of chronic diseases such as cancer, diabetes, cardiovascular disorders, and neurodegenerative conditions. This review synthesizes current knowledge on plant-derived antioxidants, emphasizing their mechanisms, therapeutic potential, and quantitative efficacy validated through standardized assays. Key phytochemicals, including polyphenols, carotenoids, flavonoids, and terpenoids, neutralize reactive oxygen species (ROS) through radical scavenging, enzyme modulation, and gene regulation. For instance, lutein, a carotenoid found in leafy greens, demonstrates potent antioxidant activity with IC₅₀ values… More >

Young Mae Ko, Tae Hyon Kim^*

BIOCELL, Vol.49, No.7, pp. 1141-1168, 2025, DOI:10.32604/biocell.2025.065464 - 25 July 2025

Abstract Ginsenosides, the bioactive saponins primary found in Panax ginseng, possess a complex structure that underlies their diverse pharmacological properties. Ginsenoside Rg3 stands out for its broad therapeutic potential, including anticancer, anti-inflammatory, neuroprotective, and cardiovascular effects. This review provides a comprehensive overview of the cellular and molecular mechanisms of Rg3, emphasizing its roles in regulating apoptosis, inflammation, oxidative stress, and metabolic pathways relevant to skincare and anticancer applications. The unique biological activities of its isomeric forms, 20(S)-Rg3 and 20(R)-Rg3, are highlighted, alongside strategies to enhance its bioavailability, such as nanoencapsulation and prodrug design. Additionally, the synergistic effects More >

FLáVIA ALVES VERZA^1,#,*, GUILHERME CARVALHO DA SILVA^2,#, FELIPE GARCIA NISHIMURA²

Oncology Research, Vol.33, No.8, pp. 1819-1834, 2025, DOI:10.32604/or.2025.065755 - 18 July 2025

Abstract Cancer remains a major global health burden, with rising incidence and mortality linked to aging populations and increased exposure to genotoxic agents. Oxidative stress plays a critical role in cancer development, progression, and resistance to therapy. The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1)-antioxidant response element (ARE) signaling pathway is central to maintaining redox balance by regulating the expression of antioxidant and detoxification genes. Under physiological conditions, this pathway protects cells from oxidative damage, however, sustained activation of NRF2 in cancer, often due to mutations in KEAP1, supports tumor cell survival, More > Graphic Abstract

Jackson Silva Nóbrega^1,*, Geovani Soares de Lima¹, Jean Telvio Andrade Ferreira², Julio Cesar Agostinho da Silva¹, Lauriane Almeida dos Anjos Soares¹, Valéria Fernandes de Oliveira Sousa¹, Paulo Vinicius de Oliveira Freire¹, Reynaldo Teodoro de Fátima¹, Flávia de Sousa Almeida¹, Hans Raj Gheyi², Josemir Moura Maia³

Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1587-1600, 2025, DOI:10.32604/phyton.2025.063633 - 29 May 2025

Abstract The Northeast region is the main producer of guava in Brazil, generating employment and income. However, water availability means that producer’s resort to using water with high salinity, which harms plant development, especially during the seedling formation phase. The adoption of techniques that mitigate the deleterious effect of salinity is increasingly necessary, such as the use of elicitors such as ascorbic acid. The purpose of this study was to analyze the morphophysiology of guava seedlings under saline and ascorbic acid levels. The study was carried out by applying treatments composed of five saline levels (SL… More >