XIAODAN SONG^1,#, YUQING WANG^1,#, XIUMEI CHENG^2,3,*, XIAOYUN ZHANG², DI WANG⁴, YANQING REN⁵, XINHUA LI⁴, XIAOQIAN DI¹, SISI XUE², TIANYUAN LV¹

BIOCELL, Vol.48, No.12, pp. 1761-1772, 2024, DOI:10.32604/biocell.2024.057203 - 30 December 2024

Abstract Background: Prior research has established that exposure to low temperatures adversely affects ovarian function, yet the precise mechanisms remain to be elucidated. Methods: Thirty experimental rats, each demonstrating two regular estrous cycles, were assorted randomly into three distinct groups: a control group, a cold exposure group, and a group treated with 4-phenylbutyric acid (4-PBA). To mimic the conditions of cold exposure, rats in the cold exposure and 4-PBA groups were subjected to immersion in ice water for 21 days. After 7 days of exposure to ice water, the 4-PBA group received intraperitoneal injections of a… More >

ANA S. CVETANOVIC^1,2,*, MATTEO LAMBERTINI^3,4, KEVIN PUNIE⁵, GORANA G. MATOVINA BRKO⁶, NIKOLA D. ZIVKOVIC^7,8, MAJA J. POPOVIC^6,9, MARIJANA M. MILOVIC KOVACEVIC¹⁰, LAZAR S. POPOVIC^6,9

Oncology Research, Vol.32, No.8, pp. 1309-1322, 2024, DOI:10.32604/or.2024.049743 - 17 July 2024

Abstract Oncofertility is an extremely significant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but significantly contributes to preserving life quality. The effect of chemotherapy can range from minimal effects to complete ovarian atrophy. Limited data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and fertility. Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy decreases the gonadotoxic effect of chemotherapy, thereby diminishing the chance of developing premature ovarian insufficiency (POI).… More > Graphic Abstract