Yi Miao1, Meng Lu1, Qin Yan, Shuangdi Li, Youji Feng
Oncology Research, Vol.24, No.6, pp. 463-475, 2016, DOI:10.3727/096504016X14685034103671
Abstract Pyruvate kinase (PK) is a key enzyme in the process of glycolysis, catalyzing phosphoenolpyruvate (PEP)
into pyruvate. Currently, PK isozyme type M2 (PKM2), one subtype of PK, has been proposed as a new
tumor marker with high expression in various tumor tissues. Here we aimed to explore the effects of siRNAPKM2 on ovarian carcinoma (OC) cell lines SKOV3 and OVCAR3, in which PKM2 was notably expressed.
PKM2 gene interference lentivirus vectors were built by miRNA transfection assay. siRNA-PKM2-transfected
SKOV3 and OVCAR3 cells were evaluated for cell proliferation, cell cycle distribution, cell apoptosis, cell
migration, and More >
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