SUBHAYAN SUR^1,*, DIMPLE DAVRAY², SOUMYA BASU¹, SUPRIYA KHEUR³, JAYANTA KUMAR PAL¹, SHUCHI NAGAR², AVINASH SANAP³, BHIMAPPA M. RUDAGI³, SAMIR GUPTA⁴

Oncology Research, Vol.32, No.10, pp. 1589-1612, 2024, DOI:10.32604/or.2024.052120 - 18 September 2024

Abstract Oral squamous cell carcinoma (OSCC) is one of the most prevalent forms of head and neck squamous cell carcinomas (HNSCC) with a poor overall survival rate (about 50%), particularly in cases of metastasis. RNA-based cancer biomarkers are a relatively advanced concept, and non-coding RNAs currently have shown promising roles in the detection and treatment of various malignancies. This review underlines the function of long non-coding RNAs (lncRNAs) in the OSCC and its subsequent clinical implications. LncRNAs, a class of non-coding RNAs, are larger than 200 nucleotides and resemble mRNA in numerous ways. However, unlike mRNA,… More >

XINRU FENG¹, LI XIAO^2,*

BIOCELL, Vol.48, No.5, pp. 793-801, 2024, DOI:10.32604/biocell.2024.048395 - 06 May 2024

Abstract Background: Galectin 2 (LGALS2) is a protein previously reported to serve as a mediator of disease progression in a range of cancers. The function of LGALS2 in oral squamous cell carcinoma (OSCC), however, has yet to be explored, prompting the present study to address this literature gap. Methods: Overall, 144 paired malignant tumor tissues and paracancerous OSCC patient samples were harvested and the LGALS2 expression levels were examined through qPCR and western immunoblotting. The LGALS2 coding sequence was introduced into the pcDNA3.0 vector, to enable the overexpression of this gene, while an LGALS2-specific shRNA and… More >

XIA MU^1,2,#, YUBING HU^3,#, DANDAN WU^1,#, HONGYU YANG^1,2,*

BIOCELL, Vol.47, No.7, pp. 1449-1458, 2023, DOI:10.32604/biocell.2023.026704 - 21 June 2023

Abstract Oral squamous cell carcinoma (OSCC) is a malignant tumor triggered by the accumulation of multiple gene mutations in oral epithelial cells. Different OSCC-related biomarkers have been reported in circulation in the peripheral blood that support the occurrence and development of OSCC. Recent advances in high-throughput and highly sensitive detection methods have overcome the limitation of the low concentration of most peripheral blood biomarkers. Hence, blood biomarker detection has become an efficient screening tool for the early diagnosis of OSCC. The growing data available in public cancer and gene databases have provided new foundations for OSCC… More >

FRANCESCO PADUANO^1,2,*, EMANUELA ALTOMARE^2,3, BENEDETTA MARRELLI¹, VINCENZO DATTILO⁴, HAIZAL MOHD HUSSAINI⁵, PAUL ROY COOPER⁵, MARCO TATULLO⁶

BIOCELL, Vol.46, No.8, pp. 1827-1835, 2022, DOI:10.32604/biocell.2022.020462 - 22 April 2022

Abstract Oral Cancer (OC) is one of the most recurrent cancers in the head and neck squamous cancer (SCCHN) category. Recently, the genome-wide association studies (GWAS) have gained growing interest in the scientific community. GWAS have identified several pathways involved in the interactions among general risk factors and genomic variants affecting SCCHN. This systematic overview aims to critically evaluate the latest data reported within the scientific literature. The aim was to investigate the impact of genetic aspects on SCCHN onset and prognosis, involving other clinical and systemic co-factors. PubMed, Google Scholar, and Cancer Genetics Web databases More >

Wael Alosaimi^1,*, M. Irfan Uddin²

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.3, pp. 1387-1401, 2022, DOI:10.32604/cmes.2022.018433 - 19 April 2022

Abstract Deep Learning (DL) techniques as a subfield of data science are getting overwhelming attention mainly because of their ability to understand the underlying pattern of data in making classifications. These techniques require a considerable amount of data to efficiently train the DL models. Generally, when the data size is larger, the DL models perform better. However, it is not possible to have a considerable amount of data in different domains such as healthcare. In healthcare, it is impossible to have a substantial amount of data to solve medical problems using Artificial Intelligence, mainly due to… More >

WEI PAN^1,2,3,*, YE HE¹, MENGDONG HE^1,2,3, FEI WANG^1,2,3, LIHUA QIU^1,2

BIOCELL, Vol.46, No.4, pp. 1079-1088, 2022, DOI:10.32604/biocell.2022.016934 - 15 December 2021

Abstract Photodynamic therapy (PDT) has emerged as a novel therapeutic modality for cancer treatment, but its therapeutic efficacy is severely limited by the hypoxic tumor microenvironment (TME). Here we designed an innovative multifunctional nano-platform which consists of a hollow MnO₂ shell and internal photosensitizer IR780. It is not only used for multimodal imaging of oral squamous cell carcinoma (OSCC), but also for adjustment hypoxic TME to enhance cancer treatment. Hollow MnO₂ can promote decomposition of tumor endogenous H₂O₂ to relieve tumor hypoxia, thereby enhancing the effect of photodynamic therapy. Photosensitizer IR780 generates singlet oxygen under laser irradiation to More >

XIAOXU LI, YUN WANG, JUAN FANG, ZHI WANG, XIAOAN TAO, JUAN XIA, BIN CHENG^*

BIOCELL, Vol.46, No.2, pp. 441-451, 2022, DOI:10.32604/biocell.2021.014844 - 20 October 2021

Abstract Head and neck squamous cell carcinoma is the sixth most common tumor worldwide, and half of head and neck squamous cell carcinoma patients are with oral squamous cell carcinoma (OSCC). 300,000 new cases of OSCC were reported annually. Even with multi-modality treatment, the prognosis of OSCC remains unsatisfactory. Thus, it is urgent to discover novel therapeutic targets for OSCC. Some microarray studies have revealed that Keratin 4 (KRT4) is downregulated in OSCC, whereas its role in OSCC development remains unknown. The present study revealed that KRT4 suppressed OSCC progression by inducing cell apoptosis and inhibiting More >

Xubin Yin¹, Bing Yang², Ming Su², Shaoshan Sun¹, Hao Wang^1,*

Oncologie, Vol.23, No.4, pp. 533-546, 2021, DOI:10.32604/oncologie.2021.018705 - 31 December 2021

Abstract Background: Tumor recurrence is one of the major problems that affect the postoperative efficacy of oral squamous cell carcinoma (OSCC) treatment. Autophagy is known to have a dual-sided effect on tumors. However, studies on autophagy and prognosis are limited. The purpose of this study is to analyze the relationship between autophagy and OSCC recurrence. Materials and methods: 72 patients with OSCC were followed for 5 years after curative surgery. Tissue specimens from each patient were divided into tumor, normal, and marginal groups. Autophagy protein expression was assessed by western blotting and immunofluorescence. Statistical significance was evaluated using… More >

Yong Wang^*, Rui-Zhi Jia^*, Shu Diao^*, Jun He^†, Li Jia^†

Oncology Research, Vol.28, No.2, pp. 203-212, 2020, DOI:10.3727/096504019X15761480623959

Abstract Despite the considerable knowledge on the involvement of microRNA-101 (miR-101) in the evolution of oral squamous cell carcinoma (OSCC), the underlying mechanisms remain obscure. In this study, miR-101 expression was markedly downregulated in the OSCC cell lines and tissues. Cell counting kit-8 (CCK-8), ethynyl deoxyuridine (EdU), and colony formation assays showed that miR-101 inhibited the proliferation of OSCC cells. Flow cytometry and caspase 3 activity assays indicated that miR-101 induced OSCC cell apoptosis. Transwell assays demonstrated that this miRNA also repressed OSCC cell migration and invasion. Moreover, tube formation assay showed that miR-101 abated the More >

Jie REN¹, Qian LIANG²

BIOCELL, Vol.43, No.3, pp. 199-206, 2019, DOI:10.32604/biocell.2019.07128

Abstract This study aimed to investigate the role of high mobility group box-1 (HMGB1) expression in oral squamous cell carcinoma; HMGB1 promoted the proliferation and invasion of oral squamous cell carcinoma via activating epithelial-mesenchymal transformation (EMT). In this study, RNA transfection was used to silence the expression of HMGB1 in oral squamous cell carcinoma cells. CCK-8, cell clone formation and trans-well assays were used to detect the proliferation and invasion of cells before and after HMGB1 silencing. qRT-PCR and Western blot were used to detect changes in EMT marker protein expression before and after transfection.… More >