HYEON JU LEE¹, CHANG SEOP LEE¹, SI HOON KIM¹, SOOKYUNG KIM¹, JEONG MI KIM¹, SUN-WHA IM¹, YU-JIN JUNG², SEUNG-PYO HONG³, HYUNJUNG LEE³, JONG-IL KIM^3,4,5, JEONG A. HAN^1,*

BIOCELL, Vol.48, No.10, pp. 1455-1464, 2024, DOI:10.32604/biocell.2024.054538 - 02 October 2024

Abstract Objective: Transformation from normal cells to malignant cells is the basis for tumorigenesis. While this cell transformation is known to result from aberrant activation or inactivation of associated genes, these genes have not yet been fully identified. In addition, DNAJs, proteins with a J domain, are known to be molecular co-chaperones, but their cellular functions remain largely unexplored. In this context, we here identified DNAJA4, DNAJB11, and DNAJC10 as pro-transforming genes and elucidated their action mechanisms. Methods: Senescence-associated (SA)-β-galactosidase staining and western blotting were used to analyze cellular senescence and protein expression. Soft agar assay was used… More >

CHUN-HUA WANG^1,2, LU-KAI WANG³, RONG-YAUN SHYU⁴, FU-MING TSAI^5,*

BIOCELL, Vol.48, No.9, pp. 1285-1297, 2024, DOI:10.32604/biocell.2024.053746 - 04 September 2024

Abstract Tazarotene-induced gene 1 (TIG1) is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of cancer. TIG1 is widely expressed in various tissues; yet in many cancer tissues, it is not expressed because of the methylation of its promoter. Additionally, the expression of TIG1 in cancer cells inhibits their growth and invasion, suggesting that TIG1 acts as a tumor suppressor gene. However, in some cancers, poor prognosis is associated with TIG1 expression, indicating its protumor growth characteristics, especially in promoting the invasion of inflammatory breast cancer More >

XIAOBI HUANG^1,#, CHUNYUAN CHEN², YONGYANG CHEN^1,#, HONGLIAN ZHOU¹, YONGHUA CHEN¹, ZHONG HUANG¹, YULIU XIE¹, BAIYANG LIU¹, YUDONG GUO¹, ZHIXIONG YANG¹, GUANGHUA CHEN^3,*, WENMEI SU^1,4,*

Oncology Research, Vol.32, No.7, pp. 1185-1195, 2024, DOI:10.32604/or.2023.030771 - 20 June 2024

Abstract Background: Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes. Their dysregulation has been closely associated with tumorigenesis. LINC00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this cancer. However, the mechanism underlying its function in cancer progression remains poorly understood. Methods: Here, the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines, clinical samples, and xenografts. Results: We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients, whereas knockdown of LINC00265 inhibited proliferation… More >

LIJUAN ZHANG^1,#, QINGYIN MENG^2,#, LI ZHUANG¹, QUAN GONG¹, XIANDA HUANG³, XUEQIN LI¹, SHIJUAN LI¹, GUOQIN WANG⁴, XICAI WANG^5,*

BIOCELL, Vol.48, No.4, pp. 581-590, 2024, DOI:10.32604/biocell.2024.047260 - 09 April 2024

Abstract Background: Lung adenocarcinoma is a very pervasive histological form of lung cancers, and inhibiting metastasis is crucial for effective treatment. In this investigation, we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain (PHTF2) in dictating the aggressiveness and metastasis of lung adenocarcinoma. Method: We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal tissues. Cellular experiments including cell count kit (CCK)-8 growth assay, apoptosis analysis, migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma cells.… More > Graphic Abstract

SHAHID HUSSAIN^1,*, HABIB BOKHARI¹, XINGXING FAN², SHAUKAT IQBAL MALIK³, SUNDAS IJAZ¹, MUHAMMAD ADNAN SHEREEN⁴, AIMAN FATIMA³

BIOCELL, Vol.48, No.3, pp. 403-413, 2024, DOI:10.32604/biocell.2024.044801 - 15 March 2024

Abstract The global incidence of lung cancer is marked by a considerably elevated mortality rate. MicroRNAs (miRNAs) exert pivotal influence in the intricate orchestration of gene regulation, and their dysregulation can precipitate dire consequences, notably cancer. Within this context, miRNAs encapsulated in exosomes manifest a diversified impact on the landscape of lung cancer, wherein their actions may either foster angiogenesis, cell proliferation, and metastasis, or counteract these processes. This comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung cancer. Tumor-suppressive miRNAs, such as miR-204, miR-192, miR-30a, miR-34a, miR-34b, miR-203,… More >

JINNI MA^#, MEILIN ZHOU^#, XIN XU, XINYAO GAO, HAIXIA WANG, JINHUA SHEN, LU XUE^*

BIOCELL, Vol.48, No.2, pp. 239-252, 2024, DOI:10.32604/biocell.2023.045076 - 23 February 2024

Abstract Background: Placenta specific 8 (PLAC8) is a candidate oncogene involved in the development and progression of solid tumors. However, the status of PLAC8 in lung cancer (LC), especially non-small cell lung cancer (NSCLC) is still not lucid. Methods: Tissue microarray analysis (TMA) was performed to detect the expression patterns of PLAC8 in LC tissues and cell lines. Then a series of cellular experiments were performed fto assess cell proliferation, cell cycle profiles, and cell motility to explore the role of PLAC8 in NSCLC-derived cell lines: H1299 and A549. Results: TMA results showed that PLAC8 played complex More >

XINGBO WU, DAN PAN, SHOUYI TANG, YINGQIANG SHEN^*

BIOCELL, Vol.47, No.7, pp. 1459-1472, 2023, DOI:10.32604/biocell.2023.028790 - 21 June 2023

Abstract The term “undruggable” is to describe molecules that are not targetable or at least hard to target pharmacologically. Unfortunately, some targets with potent oncogenic activity fall into this category, and currently little is known about how to solve this problem, which largely hampered drug research on human cancers. Ras, as one of the most common oncogenes, was previously considered “undruggable”, but in recent years, a few small molecules like Sotorasib (AMG-510) have emerged and proved their targeted anti-cancer effects. Further, myc, as one of the most studied oncogenes, and tp53, being the most common tumor suppressor genes,… More >

Robabeh Faghani Baladehi^1,2, Mohammad Yousef Memar¹, Abolfazl Jafari Sales³, Ahad Bazmani^1,4, Javid Sadri Nahand^1,5,6, Parisa Shiri Aghbash^2,7, Hossein Bannazadeh Baghi^1,2,7,*

Oncologie, Vol.24, No.2, pp. 227-245, 2022, DOI:10.32604/oncologie.2022.020648 - 29 June 2022

Abstract The ability of host cells to activate apoptosis is perhaps the most potent weapon for helping cells eliminate viruses. Human papillomaviruses (HPV) activate several pathways, enabling the infected cells to avoid extrinsic and intrinsic apoptosis pathways. The incapacity of prostatic epithelial cells to induce apoptosis leads to the invasive development of prostate cancer. For the pathogenesis of prostate cancer, several risk factors have been reported; for example, some viruses and infectious diseases have been proposed as causative agents for their relation to prostate diseases. According to several studies, high-risk human papillomaviruses cause malignancy by interfering More >

YUHUA ZOU^1,#, LEI ZHANG^2,#, XIN ZHONG^3,*

BIOCELL, Vol.46, No.5, pp. 1309-1317, 2022, DOI:10.32604/biocell.2022.018167 - 06 January 2022

Abstract Renal cell carcinoma (RCC) has a poor prognosis due to limited diagnosis and treatment. Thus, it is necessary to find novel prognostic biomarkers and therapeutic targets. The aberrant expression of microRNAs plays an important role in RCC oncogenesis. Tissue inhibitors of metalloproteinase 3 (TIMP3) acts as a downstream target of miR-181b. The aim of this study was to understand the role and molecular mechanism of miR-181b in RCC oncogenesis. The results showed that miR-181b expression was significantly higher in RCC tumour tissues, especially in those with significant invasion or metastasis. miR-181b overexpression promoted proliferation and… More >

JIALIN WU^1,2,#, ZEHONG CHEN³, WENWEI LIU^1,#, YONGXIN ZHANG¹, WEI FENG¹, YUJIE YUAN¹, JINNING YE¹, LIANG WANG¹, SHIRONG CAI¹, YULONG HE¹, SUIJING WU^4,*, WU SONG^1,*

Oncology Research, Vol.29, No.2, pp. 119-128, 2021, DOI:10.32604/or.2022.03178 - 13 July 2022

Abstract Objective: MicroRNA-188-5p (miR-188) enhances oncologic progression in various human malignancies. This study aimed to explore its role in colorectal cancer (CRC). Materials and Methods: Human CRC tissues paired with normal tissues, and several CRC cell lines were utilized. Real-time quantitative PCR was applied to measure the expression of miR-188. Overexpression and knockdown were used to access the function of miR-188 and to investigate whether FOXL1/Wnt signaling mediates such function. The proliferation, migration and invasion of cancer cells were evaluated by CCK8, wound-healing and transwell assays, respectively. Whether FOXL1 acted as a direct target of miR-188 was verified More >