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    ARTICLE

    Improved KNN Imputation for Missing Values in Gene Expression Data

    Phimmarin Keerin1, Tossapon Boongoen2,*

    CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 4009-4025, 2022, DOI:10.32604/cmc.2022.020261 - 27 September 2021

    Abstract The problem of missing values has long been studied by researchers working in areas of data science and bioinformatics, especially the analysis of gene expression data that facilitates an early detection of cancer. Many attempts show improvements made by excluding samples with missing information from the analysis process, while others have tried to fill the gaps with possible values. While the former is simple, the latter safeguards information loss. For that, a neighbour-based (KNN) approach has proven more effective than other global estimators. The paper extends this further by introducing a new summarization method to… More >

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