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  • Open Access

    ARTICLE

    Analysis of the role of dihydromyricetin derived from vine tea (Ampelopsis grossedentata) on multiple myeloma by activating STAT1/RIG-I axis

    WEI JIANG1, MEI ZHOU2,*

    Oncology Research, Vol.32, No.8, pp. 1359-1368, 2024, DOI:10.32604/or.2024.043423

    Abstract Multiple myeloma (MM) is a plasma cell malignancy and remains incurable as it lacks effective curative approaches; thus, novel therapeutic strategies are desperately needed. The study aimed to explore the therapeutic role of dihydromyricetin (DHM) in MM and explore its mechanisms. Human MM and normal plasma samples, human MM cell lines, and normal plasma cells were used for in vitro experiments. Cell counting kit-8 (CCK-8), flow cytometry, and trans-well assays were performed for the assessment of cell viability, apoptosis, migration, and invasion, respectively. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to assess the mRNA expression… More > Graphic Abstract

    Analysis of the role of dihydromyricetin derived from vine tea (<i>Ampelopsis grossedentata</i>) on multiple myeloma by activating STAT1/RIG-I axis

  • Open Access

    ARTICLE

    Pioneering Micro-Scale Mapping of Urban CO Emissions from Fossil Fuels with GIS

    Loghman Khodakarami*

    Revue Internationale de Géomatique, Vol.33, pp. 221-246, 2024, DOI:10.32604/rig.2024.050908

    Abstract Urban areas globally are escalating contributors to carbon dioxide (CO) emissions, challenging sustainable development. This study proposes a novel micro-scale approach utilizing GIS to quantify CO emission spatial distribution, enhancing urban sustainability assessment. Employing a “bottom-up” methodology, emissions were calculated for various sources, revealing Isfahan’s urban area emits 13,855,525 tons of CO annually. Major contributors include stationary and mobile sources such as power plants (50.61%), road and rail transport (17.18%), and residential sectors (21.78%). Spatial distribution mapping showed that 81.68% of CO emissions originate from stationary sources, notably power plants. Furthermore, mobile sources, including road More >

  • Open Access

    ARTICLE

    Improving VQA via Dual-Level Feature Embedding Network

    Yaru Song*, Huahu Xu, Dikai Fang

    Intelligent Automation & Soft Computing, Vol.39, No.3, pp. 397-416, 2024, DOI:10.32604/iasc.2023.040521

    Abstract Visual Question Answering (VQA) has sparked widespread interest as a crucial task in integrating vision and language. VQA primarily uses attention mechanisms to effectively answer questions to associate relevant visual regions with input questions. The detection-based features extracted by the object detection network aim to acquire the visual attention distribution on a predetermined detection frame and provide object-level insights to answer questions about foreground objects more effectively. However, it cannot answer the question about the background forms without detection boxes due to the lack of fine-grained details, which is the advantage of grid-based features. In… More >

  • Open Access

    ARTICLE

    The Association between Fear of COVID-19, Obsession with COVID-19, and Post Traumatic Stress Disorder in Korean Emergency Rescue Firefighters: A Cross-Sectional Study

    Yun-Jung Choi1, Heewon Song2,*

    International Journal of Mental Health Promotion, Vol.26, No.6, pp. 475-480, 2024, DOI:10.32604/ijmhp.2024.050824

    Abstract During the rapid spread of COVID-19, first responders are at risk of being exposed to COVID-19 due to their role in providing first aid and responding to an unspecified number of people. This uncertainty can have adverse mental health effects, such as increased anxiety and fear. This study aimed to investigate the degree of association between fear of COVID-19, obsession with COVID-19, and post-traumatic stress disorder (PTSD) in emergency rescue firefighters. The participants were 150 emergency rescue firefighters working in Region S, Korea. They filled out self-report questionnaires: The data obtained through the Fear of… More >

  • Open Access

    ARTICLE

    Oscillatory Dynamics of a Spherical Solid in a Liquid in an Axisymmetric Variable Cross Section Channel

    Ivan Karpunin*

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1219-1232, 2024, DOI:10.32604/fdmp.2024.051062

    Abstract The dynamics of a solid spherical body in an oscillating liquid flow in a vertical axisymmetric channel of variable cross section is experimentally studied. It is shown that the oscillating liquid leads to the generation of intense averaged flows in each of the channel segments. The intensity and direction of these flows depend on the dimensionless oscillating frequency. In the region of studied frequencies, the dynamics of the considered body is examined when the primary vortices emerging in the flow occupy the whole region in each segment. For a fixed frequency, an increase in the… More >

  • Open Access

    ARTICLE

    SFGA-CPA: A Novel Screening Correlation Power Analysis Framework Based on Genetic Algorithm

    Jiahui Liu1,2, Lang Li1,2,*, Di Li1,2, Yu Ou1,2

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4641-4657, 2024, DOI:10.32604/cmc.2024.051613

    Abstract Correlation power analysis (CPA) combined with genetic algorithms (GA) now achieves greater attack efficiency and can recover all subkeys simultaneously. However, two issues in GA-based CPA still need to be addressed: key degeneration and slow evolution within populations. These challenges significantly hinder key recovery efforts. This paper proposes a screening correlation power analysis framework combined with a genetic algorithm, named SFGA-CPA, to address these issues. SFGA-CPA introduces three operations designed to exploit CPA characteristics: propagative operation, constrained crossover, and constrained mutation. Firstly, the propagative operation accelerates population evolution by maximizing the number of correct bytes… More >

  • Open Access

    ARTICLE

    CrossLinkNet: An Explainable and Trustworthy AI Framework for Whole-Slide Images Segmentation

    Peng Xiao1, Qi Zhong2, Jingxue Chen1, Dongyuan Wu1, Zhen Qin1, Erqiang Zhou1,*

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4703-4724, 2024, DOI:10.32604/cmc.2024.049791

    Abstract In the intelligent medical diagnosis area, Artificial Intelligence (AI)’s trustworthiness, reliability, and interpretability are critical, especially in cancer diagnosis. Traditional neural networks, while excellent at processing natural images, often lack interpretability and adaptability when processing high-resolution digital pathological images. This limitation is particularly evident in pathological diagnosis, which is the gold standard of cancer diagnosis and relies on a pathologist’s careful examination and analysis of digital pathological slides to identify the features and progression of the disease. Therefore, the integration of interpretable AI into smart medical diagnosis is not only an inevitable technological trend but… More >

  • Open Access

    ARTICLE

    HCRVD: A Vulnerability Detection System Based on CST-PDG Hierarchical Code Representation Learning

    Zhihui Song, Jinchen Xu, Kewei Li, Zheng Shan*

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4573-4601, 2024, DOI:10.32604/cmc.2024.049310

    Abstract Prior studies have demonstrated that deep learning-based approaches can enhance the performance of source code vulnerability detection by training neural networks to learn vulnerability patterns in code representations. However, due to limitations in code representation and neural network design, the validity and practicality of the model still need to be improved. Additionally, due to differences in programming languages, most methods lack cross-language detection generality. To address these issues, in this paper, we analyze the shortcomings of previous code representations and neural networks. We propose a novel hierarchical code representation that combines Concrete Syntax Trees (CST)… More >

  • Open Access

    ARTICLE

    Developing a Model for Parkinson’s Disease Detection Using Machine Learning Algorithms

    Naif Al Mudawi*

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4945-4962, 2024, DOI:10.32604/cmc.2024.048967

    Abstract Parkinson’s disease (PD) is a chronic neurological condition that progresses over time. People start to have trouble speaking, writing, walking, or performing other basic skills as dopamine-generating neurons in some brain regions are injured or die. The patient’s symptoms become more severe due to the worsening of their signs over time. In this study, we applied state-of-the-art machine learning algorithms to diagnose Parkinson’s disease and identify related risk factors. The research worked on the publicly available dataset on PD, and the dataset consists of a set of significant characteristics of PD. We aim to apply… More >

  • Open Access

    ARTICLE

    A New Solution to Intrusion Detection Systems Based on Improved Federated-Learning Chain

    Chunhui Li1,*, Hua Jiang2

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4491-4512, 2024, DOI:10.32604/cmc.2024.048431

    Abstract In the context of enterprise systems, intrusion detection (ID) emerges as a critical element driving the digital transformation of enterprises. With systems spanning various sectors of enterprises geographically dispersed, the necessity for seamless information exchange has surged significantly. The existing cross-domain solutions are challenged by such issues as insufficient security, high communication overhead, and a lack of effective update mechanisms, rendering them less feasible for prolonged application on resource-limited devices. This study proposes a new cross-domain collaboration scheme based on federated chains to streamline the server-side workload. Within this framework, individual nodes solely engage in… More >

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