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  • Open Access

    ARTICLE

    Kaempferol ameliorated levodopa-induced dyskinesia in experimental rats: A role of brain monoamines, cFOS, FosB, Parkin, Pdyn, TH, and p-JNK

    PEI QIN#, MIAO LIU#, XIN WANG, JIANHUA MA*

    BIOCELL, Vol.48, No.3, pp. 513-523, 2024, DOI:10.32604/biocell.2023.045640

    Abstract Background: L-dopa (Levodopa) is well known for managing PD (Parkinson’s disease); however, its prolonged use caused dyskinesia (LID). Due to the varied presentation of LID, effective treatment options are scarce. Flavonoids reported their neuroprotective activity by ameliorating acetylcholinesterase, monoamine oxidase, and neuroinflammation. Kaempferol is another flavonoid bearing these potentials. Aim: To evaluate neuroprotective activity of kaempferol in dyskinetic rats. Methods: PD was developed in Sprague-Dawley rats by injecting combination of L-ascorbic acid (10 µL) + 6-OHDA (12 µg) in medial forebrain bundle to induce neuronal damage in substantial nigra (SNr). LID was induced by administrating combination of L-dopa (20 mg/kg)… More > Graphic Abstract

    Kaempferol ameliorated levodopa-induced dyskinesia in experimental rats: A role of brain monoamines, cFOS, FosB, Parkin, Pdyn, TH, and p-JNK

  • Open Access

    ARTICLE

    Design and Evaluation of Thin-Walled Hollow-Core WoodStrand Sandwich Panels

    Christopher Voth1, Nathan White2, Vikram Yadama3,*, William Cofer3

    Journal of Renewable Materials, Vol.3, No.3, pp. 234-243, 2015, DOI:10.7569/JRM.2015.634109

    Abstract Part of a long-term goal of developing a sustainable composite panel that meets both structural and energy performance requirements in building construction applications, this study discusses the development of a thinwalled wood-strand 3D core element that shows promise for a variety of panelized construction applications, such as in a building envelope. Sandwich panels take advantage of the lightweight corrugated core sandwiched between stress skin faces acting similar to an I-beam. Specific bending stiffness of sandwich panels fabricated with ponderosa pine strands was significantly higher than average values of commercially produced composite panels of equivalent thickness (141–156% and 120–133% stiffer than… More >

  • Open Access

    ARTICLE

    Research on Dynamic and Static Test Methods for Evaluating the Poisson’s Ratio of Oriented Strand Board

    Yuhao Zhou, Yuhang He, Zhaoyu Shen, Zheng Wang*

    Journal of Renewable Materials, Vol.10, No.12, pp. 3459-3476, 2022, DOI:10.32604/jrm.2022.021251

    Abstract In this article, dynamic method and static method of testing Poisson’s ratio of OSB (Oriented Strand Board) were proposed. Through modal and static numerical analyses, the position where the transverse stress is equal to zero was determined. The binary linear regression method was applied to express the gluing position of the strain gauge as a relational expression that depended on the length-width ratio and width-thickness ratio of the cantilever plate. Then the longitudinal and transverse Poisson’s ratios of OSB were measured by the given dynamic and static methods. In addition, the test results of OSB Poisson’s ratio were analyzed with… More >

  • Open Access

    ARTICLE

    Optimization of the Thermoelectric Performances of CoSbS Semiconductors Using the High-Pressure Fabrication Method

    Fang Liu1, Yonghui You2, Min Wang1,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.18, No.6, pp. 1827-1839, 2022, DOI:10.32604/fdmp.2022.019132

    Abstract CoSbS-based compounds are good thermoelectric materials with low thermal conductivity and good electrical properties, which can effectively be used to improve the efficiency of many thermoelectric conversion processes. In order to improve their properties even more, in this study a series of experiments have been conducted in the frame of the traditional solid-phase synthesis and high-pressure method. It is shown that if the mass fluctuation and stress fluctuation in the considered CoSbS system increase, the scattering probability of phonons is enhanced and the lattice thermal conductivity of the material is reduced. Adding a small amount of Se can simultaneously optimize… More >

  • Open Access

    ARTICLE

    Constitutive Activation OsbZIP62 Improves Plant Height and Yield through Regulating the Expression of Agronomic Traits Related Genes in Rice

    Shiqin Yang1,2,#, Tao Jiang3,#, Peilin Shen1, Shengjie Ren3, Zhun Gu1, Fangjun Feng2, Yunpeng Peng2,4, Wei Wang5, Kai Xu2,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.8, pp. 1671-1686, 2022, DOI:10.32604/phyton.2022.018996

    Abstract Plant height is an important morphological trait that affects crop yield. Several genes related to plant height and yield have been reported in rice (Oryza sativa L.), however, the molecular mechanism underlying the regulation of these traits is still not completely understood. VP64 is widely used as a transcriptional activator to investigate the biological function of genes encoding transcription factors. Here, we identified a novel bZIP transcription factor OsbZIP62 that is involved in modulating agronomic traits in rice. Overexpression of OsbZIP62-VP64 (OsbZIP62V) significantly increases the plant height and yield per plant in rice. RNA-seq analysis showed that some plant height… More >

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