Juan Li*†1,
Chunyan Liu‡1,
Dawei Li§, Meng Wan¶, Hong Zhang†, Xiaoxia Zheng†, Xuemei Jie†,
Pengju Zhang¶, Jingjing Li#, Hongchun Hou†, Qing Sun*
Oncology Research, Vol.27, No.7, pp. 763-771, 2019, DOI:10.3727/096504018X15399955297355
Abstract OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to
investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover
that OLFM4 expression is significantly reduced in metastatic cervical cancer. Accordingly, overexpression of
OLFM4 inhibits epithelial–mesenchymal transition (EMT), migration, and invasion in human cervical cancer
cells. To further explore its molecular mechanisms, we reveal that OLFM4 augmentation interferes with mTOR
signaling pathway, and the suppressive effects of OLFM4 on cell migration and invasion are largely weakened
by phosphatidic acid (PA)-induced mTOR More >
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