HUI ZHOU^#, ZHENGYU YU^#, JING XU, ZHONGWANG WANG, YALI TAO, JINJIN WANG, PEIPEI YANG, JINRONG YANG^*, TING NIU^*

Oncology Research, Vol.32, No.12, pp. 1903-1919, 2024, DOI:10.32604/or.2024.048138 - 13 November 2024

Abstract Background: Dihydrolipoamide S-acetyltransferase (DLAT) is a subunit of the pyruvate dehydrogenase complex (PDC), a rate-limiting enzyme complex, that can participate in either glycolysis or the tricarboxylic acid cycle (TCA). However, the pathogenesis is not fully understood. We aimed to perform a more systematic and comprehensive analysis of DLAT in the occurrence and progression of tumors, and to investigate its function in patients’ prognosis and immunotherapy. Methods: The differential expression, diagnosis, prognosis, genetic and epigenetic alterations, tumor microenvironment, stemness, immune infiltration cells, function enrichment, single-cell analysis, and drug response across cancers were conducted based on multiple computational… More > Graphic Abstract

Zhaowei Zhou¹, Kaicheng Ruan¹, Donghua Zhao¹, Yi Xiong^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.011376

Abstract Fused deposition modeling (FDM) with foaming materials offers the capability to generate internal porous structures through in-situ foaming, imparting favorable characteristics such as weight reduction, shock absorption, thermal insulation, and sound insulation to printed objects. However, the process planning for this technology presents challenges due to the difficulty in accurately controlling the foaming rate, stemming from a complex underlying mechanism that remains poorly understood. This study introduces a multi-sensor platform for FDM with foaming materials, facilitating in-situ process monitoring of temperature field information during material modeling and quality evaluation of printed objects, i.e., abnormal foaming… More >

Lan Huang¹, Wenbin Yuan¹, Hisham Essawy², Xiaojian Zhou^3,*, Xinyi Chen^3,*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.10, pp. 2219-2234, 2024, DOI:10.32604/fdmp.2024.052445 - 23 September 2024

Abstract Tannin foam is a new functional material. It can be widely applied to the automobile industry, construction industry, and packaging industry due to its wide range of raw materials, renewable, easily degraded, low cost and almost no pollution. Preparing tannin foam is a very complex process that includes high temperature, two phases, mechanical agitation, and phase change. To investigate the influence of the stirring velocity and paddle shape, simulation was calculated by making use of the volume of fluid (VOF) method and multiple reference frame (MRF) method in a three-dimensional flow field of tannin-based foaming… More > Graphic Abstract

Kun Yan¹, Yunyu Wang², Jun Yan^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1949-1974, 2024, DOI:10.32604/cmes.2024.048877 - 20 May 2024

Abstract Topology optimization of thermal-fluid coupling problems has received widespread attention. This article proposes a novel topology optimization method for laminar two-fluid heat exchanger design. The proposed method utilizes an artificial density field to create two permeability interpolation functions that exhibit opposing trends, ensuring separation between the two fluid domains. Additionally, a Gaussian function is employed to construct an interpolation function for the thermal conductivity coefficient. Furthermore, a computational program has been developed on the OpenFOAM platform for the topology optimization of two-fluid heat exchangers. This program leverages parallel computing, significantly reducing the time required for More >

Laima Vevere^*, Beatrise Sture, Vladimir Yakushin, Mikelis Kirpluks, Ugis Cabulis

Journal of Renewable Materials, Vol.12, No.3, pp. 585-602, 2024, DOI:10.32604/jrm.2024.047350 - 11 April 2024

Abstract Cryogenic insulation material rigid polyurethane (PU) foams were developed using bio-based and recycled feedstock. Polyols obtained from tall oil fatty acids produced as a side stream of wood biomass pulping and recycled polyethylene terephthalate were used to develop rigid PU foam formulations. The 4th generation physical blowing agents with low global warming potential and low ozone depletion potential were used to develop rigid PU foam cryogenic insulation with excellent mechanical and thermal properties. Obtained rigid PU foams had a thermal conductivity coefficient as low as 0.0171 W/m·K and an apparent density of 37–40 kg/m³. The developed… More > Graphic Abstract

PEI QIN^#, MIAO LIU^#, XIN WANG, JIANHUA MA^*

BIOCELL, Vol.48, No.3, pp. 513-523, 2024, DOI:10.32604/biocell.2023.045640 - 15 March 2024

Abstract Background: L-dopa (Levodopa) is well known for managing PD (Parkinson’s disease); however, its prolonged use caused dyskinesia (LID). Due to the varied presentation of LID, effective treatment options are scarce. Flavonoids reported their neuroprotective activity by ameliorating acetylcholinesterase, monoamine oxidase, and neuroinflammation. Kaempferol is another flavonoid bearing these potentials. Aim: To evaluate neuroprotective activity of kaempferol in dyskinetic rats. Methods: PD was developed in Sprague-Dawley rats by injecting combination of L-ascorbic acid (10 µL) + 6-OHDA (12 µg) in medial forebrain bundle to induce neuronal damage in substantial nigra (SNr). LID was induced by administrating combination… More > Graphic Abstract

Yuxuan Ying¹, Wei Huang^1,*, Yu-E Ma¹, Fan Peng¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.4, pp. 1-3, 2023, DOI:10.32604/icces.2023.010572

Abstract Intensive dynamic loadings are the main threats to the structural damage of protective structures and inner equipment, which has attracted a lot of attention in the field of advance impulsive resistance. Nanofluidic liquid foam (NLF) has become a novel and efficient energy absorption system due to its reusable energy absorption, ultra-high load transfer, and high energy absorption ratio. In order to solve the current problem that the energy absorption mechanism of NLF is still unclear, this paper conducted a systematic experimental study on the dynamic compression and energy absorption behaviours of NLF. The quasi-static cyclic… More >

Haoyuan Guo¹, Jianxun Zhang^1,2,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09071

Abstract In this paper, the dynamic response of clamped rectangular sandwich tubes with metal foam core under transverse blast loading is studied by analytical analysis and FE simulation. It is assumed that the local denting occurs before the overall bending, and the local denting leads to the reduction of the fully plastic bending moment of cross-section. First, based on the modified solution for the maximum deflection of the solid beam under transverse blast loading, a semiempirical analytical solution for the dynamic response of rectangular hollow metal tube is given subjected to transverse blast loading considering local… More >

Haiqi Feng¹, Wei Huang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-2, 2023, DOI:10.32604/icces.2023.09347

Abstract Intensive dynamic loadings are the main threats to the structural damage of protective structures and inner equipment, which has attracted a lot of attention in the field of advance impulsive resistance. Nanofluidic liquid foam (NLF) has become a novel and efficient energy absorption system due to its reusable energy absorption, ultra-high load transfer, and high energy absorption ratio [1-7]. In order to solve the current problem that the energy absorption mechanism of NLF is still unclear, this paper conducted a systematic experimental study on the dynamic compression and energy absorption behaviours of NLF. The quasi-static… More >

Shaopeng Liu¹, Guowei Wang^2,3,*, Pengfei Liu¹, Dong Ye¹, Jian Song¹, Xing Liu¹, Yang Cheng^2,3

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.12, pp. 3045-3058, 2023, DOI:10.32604/fdmp.2023.029810 - 27 October 2023

Abstract Foam drainage is the flow of liquid through the interstitial spaces between bubbles driven by capillarity and gravity and resisted by viscous damping. The so-called foam drainage gas recovery technology is a technique traditionally used to mitigate the serious bottom-hole liquid loading in the middle and late stages of gas well production. In this context, determining the optimal concentration of the bubble drainage agent is generally crucial for the proper application of this method. In this study, a combination of indoor experiments and theoretical analysis have been used to determine the pressure drop related to… More >