Sanae Haga*, Takeaki Ozawa†, Naoki Morita‡, Mami Asano§, Shigeki Jin¶, Yimin#, Michitaka Ozaki*§¶
Oncology Research, Vol.26, No.3, pp. 467-472, 2018, DOI:10.3727/096504017X15040166233313
Abstract Akt is commonly overexpressed and activated in cancer cells and plays a pivotal role in cell survival, protection, and chemoresistance. Therefore, Akt is one of the target molecules in understanding characters of cancer
cells and developing anticancer drugs. Here we examined whether a newly developed photo-activatable Akt
(PA-Akt) probe, based on a light-inducible protein interaction module of plant cryptochrome2 (CRY2) and
cryptochrome-interacting basic helix–loop–helix (CIB1), can regulate Akt-associated cell functions. By illuminating blue light to the cells stably transfected with PA-Akt probe, CRY2-Akt (a fusion protein of CRY2 and
Akt) underwent a structural change and… More >
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