ShiDong Li*†, JiaMei Yang†, Yubing Xia‡, QingXia Fan*, Kun-peng Yang§
Oncology Research, Vol.26, No.2, pp. 289-296, 2018, DOI:10.3727/096504017X15009404458675
Abstract Long noncoding RNAs (lncRNAs) have been implicated in various biological processes and pathological conditions, including tumorigenesis. However, the exact roles of NEAT1 and its underlying mechanisms in nonsmall cell lung cancer (NSCLC) remain largely unclear. In the present study, lncRNA NEAT1 was detected to
be significantly upregulated in NSCLC tissues and closely associated with advanced TNM stages, lymph node
metastasis, distant metastasis, and poor prognosis. Further experiments revealed that lncRNA NEAT1 silencing
inhibited cell proliferation and invasion in vitro. In addition, mechanistic analysis showed that lncRNA NEAT1
upregulated the miR-181a-5p-targeted gene HMGB2 through acting as More >
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