Cheng Zhang*, Jing-Yi Li*, Fu-Zhou Tian†, Gang Zhao‡, Hai Hu‡, Yue-Feng Ma*, Yu-Long Yang*
Oncology Research, Vol.26, No.6, pp. 879-888, 2018, DOI:10.3727/096504017X15024935181289
Abstract Long noncoding RNAs (lncRNAs) are known to play important roles in cancers. However, little is known
about lncRNAs in cholangiocarcinoma (CCA), a cholangiocyte malignancy with poor prognosis. We investigated the role of nuclear paraspeckle assembly transcript 1 (NEAT1) lncRNA in promoting CCA. qRT-PCR
analysis of patient samples showed that NEAT1 expression was higher in CCA tumors than in matched adjacent nontumor tissue. NEAT1 levels were also higher in CCA cell lines than in a normal biliary epithelium
cell line (HIBEpic). NEAT1 knockdown in CCA cell lines using shNEAT1 reduced cell proliferation and
colony formation in… More >
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