Sarah A. Scuderi*, Marika Lanza*, Giovanna Casili*, Francesca Esposito†, Cristina Colarossi‡, Dario Giuffrida‡, Paterniti Irene*, Salvatore Cuzzocrea*,* Emanuela Esposito*, Michela Campolo*
Oncology Research, Vol.28, No.7-8, pp. 779-790, 2020, DOI:10.3727/096504021X16161478258040
Abstract Glioma are common malignant brain tumors, among which glioblastoma multiforme (GBM) has the worst
prognosis. Different studies of GBM revealed that targeting nuclear factor B (NF- B) induced an attenuation
tumor proliferation and prolonged cell survival. TBK1 {TANK [TRAF (TNF (tumor-necrosis-factor) receptorassociated factor)-associated NF- B activator]-binding kinase 1} is a serine/threonine protein kinase, and it is
a member of the I B kinase (IKK) family involved in NF- B pathway activation. The aim of this study was
to investigate the potential effect of BX795, an inhibitor of TBK1, in an in vitro and ex vivo… More >
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