Xiaoyun Liu1, Shuguang Li1, Yanyan Li, Bo Cheng, Bo Tan, Gang Wang
Oncology Research, Vol.26, No.8, pp. 1227-1234, 2018, DOI:10.3727/096504018X15178736525106
Abstract Bladder cancer (BC) is a common disease of the urinary system. Puerarin is a flavonoid extracted from
Pueraria lobata. However, the role of puerarin in BC remains unclear. Hence, this study aimed to investigate
the effect of puerarin on BC cells. Cell viability, proliferation, and apoptosis were measured by CCK-8, BrdU
assay, and flow cytometry analysis, respectively. The expressions of miR-16, apoptosis-related factors, and the
main factors of the NF-kB pathway were analyzed by qRT-PCR and Western blot. In this study, we found that
cell viability and proliferation were significantly reduced, cell apoptosis was enhanced, and… More >
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