Shenggang Liu*, Hongzhong Yang†, Ying Chen‡, Baimei He§, Qiong Chen§
Oncology Research, Vol.24, No.2, pp. 81-87, 2016, DOI:10.3727/096504016X14597766487717
Abstract In order to improve therapeutic efficacy, it is a current emergency to better know the mechanisms underlying
cisplatin resistance in lung cancer cells. In this study, we aim to investigate the role of Krüppel-like factor 4
(KLF4) in cisplatin-resistant lung cancer cells. We developed cisplatin-resistant lung cancer cell line A549/
DDP, and then a battery of experiments was used to analyze the effects of KLF4 in cisplatin resistance of
lung cancer. We found that KLF4 was significantly downregulated in cisplatin-resistant A549 cells and forced
KLF4 expression inhibited cell growth and induced apoptosis. Further, we found More >
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