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Search Results (17)
  • Open Access

    ARTICLE

    CircR-ZC3HC1 mediates MiR-384-5p/SIRT1 axis to promote neuronal autophagy and relieves ischemic stroke

    MIN SHEN1,2, XIAOMAN XU1,2, GUANGLING SUN1, LIANGZHU WANG1, TAO YING1, HANG SU1, WEI WANG1, QINGHUA CAO1,*, ZHEZHE SUN1,*

    BIOCELL, Vol.48, No.3, pp. 491-499, 2024, DOI:10.32604/biocell.2023.047640

    Abstract Objective: Circular RNAs (circRNAs) have been shown to involve in pathological processes of ischemic stroke (IS), including autophagy. This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms. Methods: Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected. Hippocampal neurons were treated with oxygen and glucose deprivation (OGD) to establish IS in vitro model. The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron microscope. Cell apoptosis rate… More >

  • Open Access

    ARTICLE

    Ginsenoside Rg1 protects against ischemia-induced neuron damage by regulating the rno-miRNA-27a-3p/PPARγ axis

    YUE GUAN1,#, TINGTING ZHANG2,#, JIANAN YU3, JIAWEI LIU4, WENYUAN LI5, YUJIA ZHENG6, JIALE WANG3, YUE LIU3, FENGGUO ZHAI2,7,*

    BIOCELL, Vol.47, No.7, pp. 1583-1594, 2023, DOI:10.32604/biocell.2023.028016

    Abstract Background: A preliminary miRNA screening showed that expression levels of rno-miRNA-27a-3p were significantly increased in the serum and brain tissues of rats undergoing cerebral ischemia. In recent years, there is evidence of the protective capacity of the saponins extracted from panax ginseng and its primary active ingredient ginsenosideRg1oncerebral ischemic injury. Methods: Fetal rat neurons (FRNs) were cultured in glucose-and-serum-free medium and exposed to hypoxia to establish a cerebral ischemia model in vitro (oxygen and glucose deprivation model, OGD). Antioxidant indexes (CAT, SOD), inflammatory markers (MPO, TNF-α and IL-6), and the expression of apoptosis and proliferation associated proteins (NF kB-p65, Caspase… More >

  • Open Access

    ARTICLE

    The Neurosurgical Challenge of Primary Central Nervous System Lymphoma Diagnosis: A Multimodal Intraoperative Imaging Approach to Overcome Frameless Neuronavigated Biopsy Sampling Errors

    Roberto Altieri1,2,*, Francesco Certo1, Marco Garozzo1, Giacomo Cammarata1, Massimiliano Maione1, Giuseppa Fiumanò3, Giuseppe Broggi4, Giada Maria Vecchio4, Rosario Caltabiano4, Gaetano Magro4, Giuseppe Barbagallo1

    Oncologie, Vol.24, No.4, pp. 693-706, 2022, DOI:10.32604/oncologie.2022.025393

    Abstract Background: Intracranial lymphoma remains a challenging differential diagnosis in daily neurosurgical practice. We analyzed our early experience with a surgical series of frameless neuronavigated biopsies in Primary CNS Lymphomas (PCNSLs), highlighting the importance of using an intraoperative combined imaging protocol (5-ALA fluorescence, i-CT and 11C-MET-PET) to overcome potential targeting errors secondary to tumor volume reduction after corticosteroid therapy. Materials and Methods: All patients treated for PCNLSs at our center in a 24-month period (1/1/2019 to 31/12/2020) were analyzed. Our cohort included 6 patients (4 males), with a median age of 67 years (59–82). A total of 45 samples were evaluated… More >

  • Open Access

    VIEWPOINT

    Poly(ADP-ribose), adherens junctions, vinculin and the actin cytoskeleton: Current evidence, future perspectives and implications

    LAURA LAFON-HUGHES1,2,*

    BIOCELL, Vol.46, No.12, pp. 2531-2535, 2022, DOI:10.32604/biocell.2022.022713

    Abstract Poly(ADP-ribose) (PAR) is a highly negatively charged polymer. PAR is synthesized by poly(ADP-ribose)polymerases (PARPs) and is involved in the assembly and stabilization of macromolecular complexes. Here, the presence and putative roles of poly(ADP-ribosyl)ation (PARylation) associated to adherens junctions (AJ) and the actin cytoskeleton in epithelial and Schwann cells, is reviewed. The hypothesis generated by analogy, stating that PAR is associated to AJ in other cell types, is postulated. According to this hypothesis, PAR associated to puncta adherentia in chemical synapses would participate in plasticity, learning and memory. In turn, PAR associated to fascia adherens in cardiomyocytes, would affect heart beating.… More >

  • Open Access

    ARTICLE

    Swarm Optimization and Machine Learning for Android Malware Detection

    K. Santosh Jhansi1,2,*, P. Ravi Kiran Varma2, Sujata Chakravarty3

    CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 6327-6345, 2022, DOI:10.32604/cmc.2022.030878

    Abstract Malware Security Intelligence constitutes the analysis of applications and their associated metadata for possible security threats. Application Programming Interfaces (API) calls contain valuable information that can help with malware identification. The malware analysis with reduced feature space helps for the efficient identification of malware. The goal of this research is to find the most informative features of API calls to improve the android malware detection accuracy. Three swarm optimization methods, viz., Ant Lion Optimization (ALO), Cuckoo Search Optimization (CSO), and Firefly Optimization (FO) are applied to API calls using auto-encoders for identification of most influential features. The nature-inspired wrapper-based algorithms… More >

  • Open Access

    VIEWPOINT

    Possible mechanisms of bidirectional nuclear transport during neuronal migration

    CHUYING ZHOU1, MINEKO KENGAKU1,2,*

    BIOCELL, Vol.46, No.11, pp. 2357-2361, 2022, DOI:10.32604/biocell.2022.021050

    Abstract Neuronal migration is a fundamental process of mammalian brain development. In migrating neurons, the nuclear membrane protein Nesprin-2 has been shown to serve as an adaptor to pull the nucleus along microtubule tracks. Current evidence has shown that Nesprin-2 binds to both the minus-end-directed motor dynein as well as the plus-end-directed motor kinesin. However, translocation of neuronal nucleus has long been thought to be primarily driven by dynein motors. Intriguing questions could be raised about the role of kinesin in nuclear transport and how the activities of opposing motors are coordinated through interactions with Nesprin. Combining evidence from recent studies,… More >

  • Open Access

    REVIEW

    Implications of enolase in the RANKL-mediated osteoclast activity following spinal cord injury

    RAMSHA SHAMS1,2, NAREN L. BANIK1,2,3,*, AZIZUL HAQUE1,*

    BIOCELL, Vol.45, No.6, pp. 1453-1457, 2021, DOI:10.32604/biocell.2021.017659

    Abstract Spinal Cord Injury (SCI) is a debilitating condition characterized by damage to the spinal cord, resulting in loss of function, mobility, and sensation. Although increasingly prevalent in the US, no FDA-approved therapy exists due to the unfortunate complexity of the condition, and the difficulties of SCI may be furthered by the development of SCI-related complications, such as osteoporosis. SCI demonstrates two crucial stages for consideration: the primary stage and the secondary stage. While the primary stage is suggested to be immediate and irreversible, the secondary stage is proposed as a promising window of opportunity for therapeutic intervention. Enolase, a metabolic… More >

  • Open Access

    ARTICLE

    miR-21-3p alleviates neuronal apoptosis during cerebral ischemiareperfusion injury by targeting SMAD2

    FEI TIAN*, GANG LIU, LINLIN FAN, ZHONGYUN CHEN, YAN LIANG,

    BIOCELL, Vol.45, No.1, pp. 49-56, 2021, DOI:10.32604/biocell.2021.013794

    Abstract Cerebral ischemia is due to the formation of blood clots or embolisms in the brain arteries, which leads to local brain tissue necrosis and neural cell apoptosis. Recent studies have shown that microRNA (miRNA) plays an important regulatory role in the pathological process of ischemic injury. The aim of this study is to investigate the role and the mechanism of miR-21-3p and drosophila mothers against decapentaplegic 2 (SMAD2) in cerebral ischemic reperfusion injured (CIRI) neural cells. The CIRI model was established by oxygen-glucose deprivation and recovery process for N2a cells. The cell viability and the apoptotic was evaluated by MTT… More >

  • Open Access

    ARTICLE

    Analysis of isolation of cerebral cortical neurons in rats by different methods

    JIANHUA LI1,#, YAOGANG ZHANG1,2,#, TAO ZHANG3, MEIYUAN TIAN1, JING HOU1, DENGLIANG HUANG1, YAN CHENG1,3, ZHU MAN1,3, XIAOMING SU1,3, ZHIQIN LI1, SIXIAN TONG1, XUAN ZHANG1,3, JUN DENG1,3, YUN DONG1,3, YANYAN MA1,2,3,*

    BIOCELL, Vol.44, No.2, pp. 209-215, 2020, DOI:10.32604/biocell.2020.08941

    Abstract The aim of this study was to find a way to efficiently separate neuronal cells from the cerebral cortex of adult rats, providing a reference method for rapid acquisition of neuronal cells from the adult rat brain. Fifteen SD rats were randomly divided into three groups, with five SD rats in each group. Then, neuron cells were isolated from the adult rat cerebral cortex by the grinding method, the trypsin method, and the collagenase II method, respectively. The expression of anti-NeuN in the neurons of each group was analyzed by flow cytometry. The acquisition rates and morphology of neurons of… More >

  • Open Access

    ARTICLE

    Immunohistochemistry of GluR1 subunits of AMPA receptors of rat cerebellar nerve cells

    ORLANDO J. CASTEJÓN1*, MICHAEL E. DAILEY2

    BIOCELL, Vol.33, No.2, pp. 71-80, 2009, DOI:10.32604/biocell.2009.33.071

    Abstract The localization of GluR1 subunits of ionotropic glutamate receptors in the glial cells and inhibitory neurons of cerebellar cortex and their association with the climbing and parallel fibers, and basket cell axons were studied. Samples of P14 and P21 rat cerebellar cortex were exposed to a specific antibody against GluR1 subunit(s) of AMPA receptors and were examined with confocal laser scanning microscopy. GluR1 strong immunoreactivity was confined to Purkinje cell and the molecular layer. Weak GluR1 immunoreactivity was observed surrounding some Golgi cells in the granule cell layer. Intense GluR1 immunoreactivity was localized around Purkinje, basket, and stellate cells. Purkinje… More >

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