Jingting Mei, Yang Yang^*, Zhipeng Gao, Lanlan Rui, Yijing Lin

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4883-4904, 2024, DOI:10.32604/cmc.2024.051860

Abstract Network fault diagnosis methods play a vital role in maintaining network service quality and enhancing user experience as an integral component of intelligent network management. Considering the unique characteristics of edge networks, such as limited resources, complex network faults, and the need for high real-time performance, enhancing and optimizing existing network fault diagnosis methods is necessary. Therefore, this paper proposes the lightweight edge-side fault diagnosis approach based on a spiking neural network (LSNN). Firstly, we use the Izhikevich neurons model to replace the Leaky Integrate and Fire (LIF) neurons model in the LSNN model. Izhikevich… More >

VIRAAJ VISHNU PRASAD, JENNIFER SALLY SAMSON, VENKATACHALAM DEEPA PARVATHI^*

BIOCELL, Vol.48, No.5, pp. 693-706, 2024, DOI:10.32604/biocell.2024.048776

Abstract Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an individual. In addition to aiding the regulation of aerobic and anaerobic metabolism, exercise can stimulate the synthesis of exerkine hormones in the circulatory system. Among several exerkines that have been investigated for their therapeutic potential, Brain-derived neurotrophic factor (BDNF) is considered the most promising candidate, especially in the management of neurodegenerative diseases. Owing to the ability of physical activity to enhance BDNF synthesis, several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at More > Graphic Abstract

Muhammad Umar Nasir¹, Omar Kassem Khalil², Karamath Ateeq³, Bassam SaleemAllah Almogadwy⁴, M. A. Khan⁵, Khan Muhammad Adnan^6,*

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 963-981, 2024, DOI:10.32604/cmc.2024.047874

Abstract Cervical cancer is an intrusive cancer that imitates various women around the world. Cervical cancer ranks in the fourth position because of the leading death cause in its premature stages. The cervix which is the lower end of the vagina that connects the uterus and vagina forms a cancerous tumor very slowly. This pre-mature cancerous tumor in the cervix is deadly if it cannot be detected in the early stages. So, in this delineated study, the proposed approach uses federated machine learning with numerous machine learning solvers for the prediction of cervical cancer to train… More >

MIN SHEN^1,2, XIAOMAN XU^1,2, GUANGLING SUN¹, LIANGZHU WANG¹, TAO YING¹, HANG SU¹, WEI WANG¹, QINGHUA CAO^1,*, ZHEZHE SUN^1,*

BIOCELL, Vol.48, No.3, pp. 491-499, 2024, DOI:10.32604/biocell.2023.047640

Abstract Objective: Circular RNAs (circRNAs) have been shown to involve in pathological processes of ischemic stroke (IS), including autophagy. This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms. Methods: Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected. Hippocampal neurons were treated with oxygen and glucose deprivation (OGD) to establish IS in vitro model. The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron… More >

YUE GUAN^1,#, TINGTING ZHANG^2,#, JIANAN YU³, JIAWEI LIU⁴, WENYUAN LI⁵, YUJIA ZHENG⁶, JIALE WANG³, YUE LIU³, FENGGUO ZHAI^2,7,*

BIOCELL, Vol.47, No.7, pp. 1583-1594, 2023, DOI:10.32604/biocell.2023.028016

Abstract Background: A preliminary miRNA screening showed that expression levels of rno-miRNA-27a-3p were significantly increased in the serum and brain tissues of rats undergoing cerebral ischemia. In recent years, there is evidence of the protective capacity of the saponins extracted from panax ginseng and its primary active ingredient ginsenosideRg1oncerebral ischemic injury. Methods: Fetal rat neurons (FRNs) were cultured in glucose-and-serum-free medium and exposed to hypoxia to establish a cerebral ischemia model in vitro (oxygen and glucose deprivation model, OGD). Antioxidant indexes (CAT, SOD), inflammatory markers (MPO, TNF-α and IL-6), and the expression of apoptosis and proliferation associated… More >

Roberto Altieri^1,2,*, Francesco Certo¹, Marco Garozzo¹, Giacomo Cammarata¹, Massimiliano Maione¹, Giuseppa Fiumanò³, Giuseppe Broggi⁴, Giada Maria Vecchio⁴, Rosario Caltabiano⁴, Gaetano Magro⁴, Giuseppe Barbagallo¹

Oncologie, Vol.24, No.4, pp. 693-706, 2022, DOI:10.32604/oncologie.2022.025393

Abstract Background: Intracranial lymphoma remains a challenging differential diagnosis in daily neurosurgical practice. We analyzed our early experience with a surgical series of frameless neuronavigated biopsies in Primary CNS Lymphomas (PCNSLs), highlighting the importance of using an intraoperative combined imaging protocol (5-ALA fluorescence, i-CT and ¹¹C-MET-PET) to overcome potential targeting errors secondary to tumor volume reduction after corticosteroid therapy. Materials and Methods: All patients treated for PCNLSs at our center in a 24-month period (1/1/2019 to 31/12/2020) were analyzed. Our cohort included 6 patients (4 males), with a median age of 67 years (59–82). A total of 45 samples… More >

LAURA LAFON-HUGHES^1,2,*

BIOCELL, Vol.46, No.12, pp. 2531-2535, 2022, DOI:10.32604/biocell.2022.022713

Abstract Poly(ADP-ribose) (PAR) is a highly negatively charged polymer. PAR is synthesized by poly(ADP-ribose)polymerases (PARPs) and is involved in the assembly and stabilization of macromolecular complexes. Here, the presence and putative roles of poly(ADP-ribosyl)ation (PARylation) associated to adherens junctions (AJ) and the actin cytoskeleton in epithelial and Schwann cells, is reviewed. The hypothesis generated by analogy, stating that PAR is associated to AJ in other cell types, is postulated. According to this hypothesis, PAR associated to puncta adherentia in chemical synapses would participate in plasticity, learning and memory. In turn, PAR associated to fascia adherens in cardiomyocytes, would affect More >

K. Santosh Jhansi^1,2,*, P. Ravi Kiran Varma², Sujata Chakravarty³

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 6327-6345, 2022, DOI:10.32604/cmc.2022.030878

Abstract Malware Security Intelligence constitutes the analysis of applications and their associated metadata for possible security threats. Application Programming Interfaces (API) calls contain valuable information that can help with malware identification. The malware analysis with reduced feature space helps for the efficient identification of malware. The goal of this research is to find the most informative features of API calls to improve the android malware detection accuracy. Three swarm optimization methods, viz., Ant Lion Optimization (ALO), Cuckoo Search Optimization (CSO), and Firefly Optimization (FO) are applied to API calls using auto-encoders for identification of most influential More >

CHUYING ZHOU¹, MINEKO KENGAKU^1,2,*

BIOCELL, Vol.46, No.11, pp. 2357-2361, 2022, DOI:10.32604/biocell.2022.021050

Abstract Neuronal migration is a fundamental process of mammalian brain development. In migrating neurons, the nuclear membrane protein Nesprin-2 has been shown to serve as an adaptor to pull the nucleus along microtubule tracks. Current evidence has shown that Nesprin-2 binds to both the minus-end-directed motor dynein as well as the plus-end-directed motor kinesin. However, translocation of neuronal nucleus has long been thought to be primarily driven by dynein motors. Intriguing questions could be raised about the role of kinesin in nuclear transport and how the activities of opposing motors are coordinated through interactions with Nesprin. More >

RAMSHA SHAMS^1,2, NAREN L. BANIK^1,2,3,*, AZIZUL HAQUE^1,*

BIOCELL, Vol.45, No.6, pp. 1453-1457, 2021, DOI:10.32604/biocell.2021.017659

Abstract Spinal Cord Injury (SCI) is a debilitating condition characterized by damage to the spinal cord, resulting in loss of function, mobility, and sensation. Although increasingly prevalent in the US, no FDA-approved therapy exists due to the unfortunate complexity of the condition, and the difficulties of SCI may be furthered by the development of SCI-related complications, such as osteoporosis. SCI demonstrates two crucial stages for consideration: the primary stage and the secondary stage. While the primary stage is suggested to be immediate and irreversible, the secondary stage is proposed as a promising window of opportunity for… More >