Fangjin Lu*, Bin Mu†, Ge Jin*, Lin Zhu‡, Ping Mu§
Oncology Research, Vol.29, No.1, pp. 1-10, 2021, DOI:10.3727/096504021X16401852341873
Abstract NeuroD1 is a neuronal differentiation factor that contains a basic helix–loop–helix (bHLH) motif. Recently,
NeuroD1 was found to be associated with tumorigenesis in neuroblastoma (NB) and is known to promote cell
proliferation and migration in these cells. Here we found that MYCN regulates the expression of NeuroD1 in
NB cells and that the downregulation of MYCN using short hairpin RNAs (shRNA) results in the inhibition
of cellular proliferation in NB cells. Moreover, the phenotype induced by MYCN shRNA was rescued by
the exogenous expression of NeuroD1. Chromatin immunoprecipitation (ChIP) assay showed that MYCN
directly binds to the E-box element in… More >
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