Akinori Sato, Takako Asano, Kazuki Okubo, Makoto Isono, Tomohiko Asano
Oncology Research, Vol.26, No.2, pp. 323-332, 2018, DOI:10.3727/096504017X14957929842972
Abstract The human immunodeficiency virus (HIV) protease inhibitor nelfinavir acts against malignancies by inducing endoplasmic reticulum (ER) stress. The HIV protease inhibitor ritonavir, on the other hand, not only
induces ER stress but also inhibits P-glycoprotein’s pump activity and thereby enhances the effects of its
substrate drugs. We therefore postulated that ritonavir in combination with nelfinavir would kill bladder cancer cells effectively by inducing ER stress cooperatively and also enhancing nelfinavir’s effect. Nelfinavir
was shown to be a P-glycoprotein substrate, and the combination of nelfinavir and ritonavir inhibited bladder cancer cell growth synergistically. It also suppressed… More >
Login
Register
