JIJIE XIAO1, HONG XIAO2, YUJUN CAI3, JIANWEI LIAO1, JUE LIU1, LIN YAO1, SHAOLIN LI1,*
Oncology Research, Vol.32, No.4, pp. 691-702, 2024, DOI:10.32604/or.2023.030767
Abstract Osteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient prognosis. Immunotherapy has shown great potential in the treatment of osteosarcoma. However, the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma treatment. The dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor microenvironment. Here, we prepared a dual pH-sensitive nanocarrier, loaded with the photosensitizer Chlorin e6 (Ce6) and CD47 monoclonal antibodies (aCD47), to deliver synergistic photodynamic and immunotherapy of osteosarcoma. On laser irradiation, Ce6 can generate More >
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