Xin Zhang*, Shaowen Li†, Chunli Dong‡, Xiuying Xie*, Yunping Zhang*
Oncology Research, Vol.25, No.2, pp. 259-265, 2017, DOI:10.3727/096504016X14732503870766
Abstract Ovarian cancer is one of the leading causes of gynecological cancer-related deaths worldwide. We investigated
the role of a newly discovered long noncoding RNA, NR_026689, in cell proliferation, metastasis, and apoptosis
in ovarian cancer cells. Our results showed that NR_026689 was overexpressed in both clinical ovarian cancer patients and cultured ovarian cancer cells. Knockdown of NR_026689 in HO-8910PM cells significantly
decreased the cell proliferative rate and the ability to form colonies. Transwell assays revealed that depletion
of NR_026689 suppressed cell migration ability by 68% and cell invasive capacity by 71% in HO-8910PM
cells. Moreover, specific More >
Login
Register
