RONG LIU^1,#, SHENG LI^2,#, SITU XIONG², FUCUN ZHENG², XIANGPENG ZHAN², JIN ZENG², BIN FU², SONGHUI XU², SHAOXING ZHU^1,*, RU CHEN^1,*

Oncology Research, Vol.32, No.11, pp. 1733-1746, 2024, DOI:10.32604/or.2024.050851 - 16 October 2024

Abstract EVI2A has emerged as a significant biomarker in various diseases; however, its biological role and mechanism in kidney renal clear cell carcinoma (KIRC) remains unexplored. We used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer assessments. Clinical relevance was evaluated through Kaplan-Meier analysis and ROC curves. The gene’s immune relevance was explored through analyses of the tumor microenvironment (TME), Tumor Immune Single-cell Hub (TISCH), immune checkpoints, and immunotherapy sensitivity. Our results indicate that EVI2A expression is upregulated in KIRC, showing correlations with tumor grade and T/N/M stage. EVI2A demonstrates high… More >

MAHER KURDI^1,*, ALAA ALKHOTANI², ABDULRAHMAN SABBAGH³, EYAD FAIZO⁴, AHMED I. LARY⁵, AHMED K. BAMAGA⁶, MAJID ALMANSOURI⁷, BADR HAFIZ⁸, THAMER ALSHARIF⁹, SALEH BAEESA⁸

Oncology Research, Vol.32, No.6, pp. 1037-1045, 2024, DOI:10.32604/or.2024.051112 - 23 May 2024

Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype… More > Graphic Abstract

Mingyue Miao^1,#, Fei Wang^1,#, Qing Li¹, Longchen Tao¹, Chenchen Dai¹, Yu Liu¹, Shujuan Han¹, Wenshuai Chen^1,*, Ping Lu^2,*

Journal of Renewable Materials, Vol.12, No.3, pp. 443-455, 2024, DOI:10.32604/jrm.2023.030412 - 11 April 2024

Abstract The rheological properties of nanocellulose aqueous suspensions play a critical role in the development of nanocellulose-based bulk materials. High-crystalline, high-aspect ratio, and slender nanofibrillated cellulose (NFC) were extracted from four biomass resources. The cellulose nanofibrils and nanofibril bundles formed inter-connected networks in the NFC aqueous suspensions. The storage moduli of the suspensions with different concentrations were higher than their corresponding loss moduli. As the concentration increased, the storage and loss modulus of NFC dispersion increased. When the shear rate increased to a certain value, there were differences in the changing trend of the rheological behavior More > Graphic Abstract

JUN LIU^1,2,3,#, WENLI LI³, RUYUE LU^1,2, JIAQING XU^1,2, CHUNHUI JIANG⁴, JUNLIN DUAN³, LINGZHI ZHANG^1,#,*, GUANFU WANG¹, JIAXI CHEN^1,2,#,*

Oncology Research, Vol.32, No.4, pp. 717-726, 2024, DOI:10.32604/or.2023.043575 - 20 March 2024

Abstract The long non-coding RNA, Negative Regulator of Antiviral Response (NRAV) has been identified as a participant in both respiratory virus replication and immune checkpoints, however, its involvement in pan-cancer immune regulation and prognosis, particularly those of hepatocellular carcinoma (HCC), remains unclear. To address this knowledge gap, we analyzed expression profiles obtained from The Cancer Genome Atlas (TCGA) database, comparing normal and malignant tumor tissues. We found that NRAV expression is significantly upregulated in tumor tissues compared to adjacent nontumor tissues. Kaplan-Meier (K-M) analysis revealed the prognostic power of NRAV, wherein overexpression was significantly linked to… More >

CAIJUAN LIU, XINGHAO LI, YUXUAN WU, JINHUI YANG, MENGHAN WANG, YUNQI MA^*

BIOCELL, Vol.48, No.3, pp. 387-401, 2024, DOI:10.32604/biocell.2024.048791 - 15 March 2024

Abstract Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor in adults, is the most malignant and still has no cure. However, the novel role of long non-coding RNAs (lncRNAs) in the pathogenesis of glioblastoma is attracting extensive attention. LncRNAs are transcribed RNA molecules over 200 nucleotides long that do not encode proteins. Unlike small non-coding RNAs, such as microRNAs (miRNAs), lncRNAs have more complex secondary and tertiary structures that enable them to interact with DNA, RNA, and proteins and perform multiple regulatory functions. LncRNAs act as molecular sponges, absorbing and sequestering other biomolecules,… More > Graphic Abstract

A. Prabha^1,*, G. Themozhi², Rama Reddy Sathi³

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 1857-1872, 2023, DOI:10.32604/iasc.2023.027442 - 19 July 2022

Abstract This research proposes a more advanced way to address Combined Economic Emission Dispatch (CEED) concerns. Economic Load Dispatch (ELD) and Economic Emission Dispatch (EED) have been implemented to reduce generating unit fuel costs and emissions. When both economics and emission targets are taken into account, the dispatch of an aggregate cost-effective emission challenge emerges. This research affords a mathematical modeling-based analytical technique for solving economic, emission, and collaborative economic and emission dispatch problems with only one goal. This study takes into account both the fuel cost target and the environmental impact of emissions. This bi-intention… More >

R. M. Ardito Marretta^∗,†, G. Barbaraci^‡

Molecular & Cellular Biomechanics, Vol.7, No.3, pp. 135-164, 2010, DOI:10.3970/mcb.2010.007.135

Abstract Upon severe DNA damage, p21 acts in a dual mode; on the one hand, it inhibits the cyclin-CDK complex for arresting the G2/M transition and on the other hand, it indirectly becomes an apoptotic factor by activating - in sequence - the retinoblastoma protein, E2F1 and APAF1 expressions. But, in a cancer cells proliferation, the mechanisms of, and participants in, the apoptosis failure remain unclear. Since the p21/p53/Mdm2 proteins network normally involves a digital response in a cancer cell, through an original design of a cell signalling-protein simulator, we demonstrate,in silico, that apoptosis phase instability More >