Jie Zhang*, Xiao-Yan Li*, Ping Hu†, Yuan-Sheng Ding*
Oncology Research, Vol.26, No.9, pp. 1411-1418, 2018, DOI:10.3727/096504018X15190844870055
Abstract Previous study indicates that long noncoding RNA NORAD could serve as a competing endogenous RNA
to pancreatic cancer metastasis. However, its role in colorectal cancer (CRC) needs to be investigated. In
the present study, we found that the expression of NORAD was significantly upregulated in CRC tissues.
Furthermore, the expression of NORAD was positively related with CRC metastasis and patients’ poor prognosis. Knockdown of NORAD markedly inhibited CRC cell proliferation, migration, and invasion but induced
cell apoptosis in vitro. In vivo experiments also indicated an inhibitory effect of NORAD on tumor growth.
Mechanistically, we found More >
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