Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1387-1387, 2024, DOI:10.32604/or.2024.055039

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1381-1381, 2024, DOI:10.32604/or.2024.055035

Abstract This article has no abstract. More >

SNJEŽANA KAŠTELAN^1,2, ANA DIDOVIĆ PAVIČIĆ³, DARIA PAŠALIĆ⁴, TAMARA NIKUŠEVA-MARTIĆ⁵, SAMIR ČANOVIĆ^3,7, PETRA KOVAČEVIĆ^1,6,*, SUZANA KONJEVODA^3,7

Oncology Research, Vol.32, No.8, pp. 1265-1285, 2024, DOI:10.32604/or.2024.048437

Abstract Uveal and conjunctival melanomas are relatively rare tumors; nonetheless, they pose a significant risk of mortality for a large number of affected individuals. The pathogenesis of melanoma at different sites is very similar, however, the prognosis for patients with ocular melanoma remains unfavourable, primarily due to its distinctive genetic profile and tumor microenvironment. Regardless of considerable advances in understanding the genetic characteristics and biological behaviour, the treatment of uveal and conjunctival melanoma remains a formidable challenge. To enhance the prospect of success, collaborative efforts involving medical professionals and researchers in the fields of ocular biology… More > Graphic Abstract

RUIFANG LI¹, XINRONG NAN^2,*, MING LI^3,*, OMAR RAHHAL³

Oncology Research, Vol.32, No.8, pp. 1323-1334, 2024, DOI:10.32604/or.2024.046965

Abstract Background: Fibroblast activation protein (FAP), a cell surface serine protease, plays roles in tumor invasion and immune regulation. However, there is currently no pan-cancer analysis of FAP. Objective: We aimed to assess the pan-cancer expression profile of FAP, its molecular function, and its potential role in head and neck squamous cell carcinoma (HNSC). Methods: We analyzed gene expression, survival status, immune infiltration, and molecular functional pathways of FAP in The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) tumors. Furthermore, to elucidate the role of FAP in HNSC, we performed proliferation, migration, and invasion assays… More >

MING ZHUANG, XUE ZHANG, LU LI, LIMING WEN, JIAMIN QIN^*

Oncology Research, Vol.32, No.8, pp. 1347-1357, 2024, DOI:10.32604/or.2024.046170

Abstract Hepatocellular carcinoma (HCC) poses a significant threat to human health. Resistance to sorafenib in the chemotherapy of HCC is a common and significant issue that profoundly impacts clinical treatment. While several members of the transmembrane (TMEM) protein family have been implicated in the occurrence and progression of HCC, the association between TMEM39b and HCC remains unexplored. This study revealed a significant overexpression of TMEM39b in HCC, which correlated with a poor prognosis. Subsequent investigation revealed that RAS-selective lethal 3 (RSL3) induced pronounced ferroptosis in HCC, and knocking down the expression of TMEM39b significantly decreased its More >

Brij B. Gupta^1,2,3,*, Akshat Gaurav⁴, Razaz Waheeb Attar⁵, Varsha Arya^6,7, Ahmed Alhomoud⁸, Kwok Tai Chui⁹

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2689-2706, 2024, DOI:10.32604/cmes.2024.050825

Abstract This study introduces a long-short-term memory (LSTM)-based neural network model developed for detecting anomaly events in care-independent smart homes, focusing on the critical application of elderly fall detection. It balances the dataset using the Synthetic Minority Over-sampling Technique (SMOTE), effectively neutralizing bias to address the challenge of unbalanced datasets prevalent in time-series classification tasks. The proposed LSTM model is trained on the enriched dataset, capturing the temporal dependencies essential for anomaly recognition. The model demonstrated a significant improvement in anomaly detection, with an accuracy of 84%. The results, detailed in the comprehensive classification and confusion More >

Weijian Song^1,, Xi Li^1,, Peng Chen^1,*, Juan Chen¹, Jianhua Ren², Yunni Xia^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 3001-3016, 2024, DOI:10.32604/cmes.2024.048563

Abstract With the rapid development of Internet of Things (IoT) technology, IoT systems have been widely applied in healthcare, transportation, home, and other fields. However, with the continuous expansion of the scale and increasing complexity of IoT systems, the stability and security issues of IoT systems have become increasingly prominent. Thus, it is crucial to detect anomalies in the collected IoT time series from various sensors. Recently, deep learning models have been leveraged for IoT anomaly detection. However, owing to the challenges associated with data labeling, most IoT anomaly detection methods resort to unsupervised learning techniques.… More >

XULONG SUN^1,#, WENTAO DING^2,#, CHAO JIANG³, ZHIAN FANG^4,*

BIOCELL, Vol.48, No.7, pp. 1071-1079, 2024, DOI:10.32604/biocell.2024.050519

Abstract Introduction: Hepatocellular carcinoma (HCC), a prevalent malignancy, poses significant challenges with high tumor heterogeneity and poor prognosis. MicroRNAs (miRNAs) play a pivotal role in hepatocarcinogenesis. Although abnormalities in microRNA-557 (miR-557) expression have been implicated in various cancer types, its role in HCC remains unclear. Therefore, there is a need to explore the function of microRNA-557 in HCC. Methods: Candidate miRNAs were identified through screening in GSE108724 and GSE20077. Real-time PCR was employed to analyze the expression level of miR-557 in hepatoma cell lines and tissues. Cell viability and migration assays were applied to assess the… More > Graphic Abstract

YAN-NAN LI^1,#, YUN-HONG XIU^2,#, YAN-JUN TANG³, JING-LONG CAO¹, WEN-SHUANG HOU¹, AN-QI WANG¹, TIAN-ZHU LI^4,*, CHENG-HAO JIN^1,3,5,*

BIOCELL, Vol.48, No.7, pp. 1055-1069, 2024, DOI:10.32604/biocell.2024.050515

Abstract Objectives: Sciadopitysin (SP) is a flavonoid in Ginkgo biloba that exhibits various pharmacological activities. This study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma (HCC) cells. Methods: Network pharmacology was used for target prediction analysis. Cell Counting Kit-8 (CCK-8) assay was used to test the cell viability. Flow cytometry was used to test the cell cycle distribution, apoptosis status, and reactive oxygen species (ROS) levels. Transwell and wound-healing assay was used to test the migration effect of SP on HepG2 cells. Western Blot assay was used to… More > Graphic Abstract

XIAOBI HUANG^1,#, CHUNYUAN CHEN², YONGYANG CHEN^1,#, HONGLIAN ZHOU¹, YONGHUA CHEN¹, ZHONG HUANG¹, YULIU XIE¹, BAIYANG LIU¹, YUDONG GUO¹, ZHIXIONG YANG¹, GUANGHUA CHEN^3,*, WENMEI SU^1,4,*

Oncology Research, Vol.32, No.7, pp. 1185-1195, 2024, DOI:10.32604/or.2023.030771

Abstract Background: Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes. Their dysregulation has been closely associated with tumorigenesis. LINC00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this cancer. However, the mechanism underlying its function in cancer progression remains poorly understood. Methods: Here, the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines, clinical samples, and xenografts. Results: We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients, whereas knockdown of LINC00265 inhibited proliferation… More >