Juhwan Kim, Baehoon Son, Jihyeon Yu, Joobeom Yun^*

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 3371-3393, 2024, DOI:10.32604/cmc.2024.057234 - 18 November 2024

Abstract Digital forensics aims to uncover evidence of cybercrimes within compromised systems. These cybercrimes are often perpetrated through the deployment of malware, which inevitably leaves discernible traces within the compromised systems. Forensic analysts are tasked with extracting and subsequently analyzing data, termed as artifacts, from these systems to gather evidence. Therefore, forensic analysts must sift through extensive datasets to isolate pertinent evidence. However, manually identifying suspicious traces among numerous artifacts is time-consuming and labor-intensive. Previous studies addressed such inefficiencies by integrating artificial intelligence (AI) technologies into digital forensics. Despite the efforts in previous studies, artifacts were… More >

Sameema Tariq¹, Ata-Ur- Rehman^2,3, Maria Abubakar², Waseem Iqbal⁴, Hatoon S. Alsagri⁵, Yousef A. Alduraywish⁵, Haya Abdullah A. Alhakbani^5,*

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2493-2515, 2024, DOI:10.32604/cmc.2024.055787 - 18 November 2024

Abstract In video surveillance, anomaly detection requires training machine learning models on spatio-temporal video sequences. However, sometimes the video-only data is not sufficient to accurately detect all the abnormal activities. Therefore, we propose a novel audio-visual spatiotemporal autoencoder specifically designed to detect anomalies for video surveillance by utilizing audio data along with video data. This paper presents a competitive approach to a multi-modal recurrent neural network for anomaly detection that combines separate spatial and temporal autoencoders to leverage both spatial and temporal features in audio-visual data. The proposed model is trained to produce low reconstruction error… More >

ZHEN WANG¹, JUN FU¹, SAISAI ZHU¹, HAODONG TANG², KUI SHI¹, JIHUA YANG³, MENG WANG³, MENGGE WU¹, DUNFENG QI^1,*

Oncology Research, Vol.32, No.12, pp. 1851-1866, 2024, DOI:10.32604/or.2024.055286 - 13 November 2024

Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) has a rich and complex tumor immune microenvironment (TIME). M2 macrophages are among the most extensively infiltrated immune cells in the TIME and are necessary for the growth and migration of cancers. However, the mechanisms and targets mediating M2 macrophage infiltration in pancreatic cancer remain elusive. Methods: The M2 macrophage infiltration score of patients was assessed using the xCell algorithm. Using weighted gene co-expression network analysis (WGCNA), module genes associated with M2 macrophages were identified, and a predictive model was designed. The variations in immunological cell patterns, cancer mutations, and… More > Graphic Abstract

SAM SON¹, AKSHAAR BRAHMBHATT¹, KEN ZHAO¹, BRETT MARINELLI¹, JAMES HARDING², WILLIAM JARNAGIN³, GHASSAN K. ABOU-ALFA², HOOMAN YARMOHAMMADI^1,*

Oncology Research, Vol.32, No.12, pp. 1831-1836, 2024, DOI:10.32604/or.2024.052985 - 13 November 2024

Abstract Background: This article aims to present the single-institution outcomes of patients with Fibrolamellar Carcinoma (FLC) treated with liver-directed therapies (LDT). Methods: In this single-center retrospective study, all patients diagnosed with FLC who underwent LDT were identified. Between July 2012 and July 2023, six patients were identified. One patient was excluded due to bleeding. Demographic and clinical parameters were recorded. Complications within 30 days of the LDT were evaluated. Radiological treatment responses at 1, 6, and 12 months were assessed per mRECIST. Results: A total of five patients, which included three females and two males, were reviewed.… More >

CHUAN JIANG^1,2, CHUNLEI LIU^1,3, XI YAO^1,3, JINGYA SU^1,2, WEI LU^1,3, ZHENGBO WEI^3,*, YING XIE^1,2,*

Oncology Research, Vol.32, No.12, pp. 1935-1948, 2024, DOI:10.32604/or.2024.052244 - 13 November 2024

Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer globally, with chemoresistance posing a major challenge in treatment outcomes. The efficacy of the commonly used chemotherapeutic agent, cisplatin, is diminished in patients with poor prognoses. Methods: Various bioinformatics databases were utilized to examine Carboxylesterase 1 (CES1) gene expression, clinicopathologic features, patient survival analysis, and gene function. An organoid model of HNSCC was established, along with the induction of drug-resistant HNSCC in the organoid model. CES1 expression was assessed using qRT-PCR and Western Blot, and differential markers were identified through transcriptome… More >

PINGHUA TU, SHANSHAN WANG, KELAN DENG, XINJUN LI, ZHANLING WU^*

BIOCELL, Vol.48, No.11, pp. 1603-1612, 2024, DOI:10.32604/biocell.2024.054364 - 07 November 2024

Abstract Objectives: The antitumor effects of pyropheophorbide-α methyl ester-mediated photodynamic therapy (MPPa-PDT) were observed in several cancers. The objective of this investigation was to examine the antineoplastic efficacy of MPPa-PDT acting on lung carcinoma A549 cells and further elaborate mechanisms. Methods: The viability of A549 cells was examined with cell counting kit-8 after MPPa-PDT disposal. Hoechst 33342 staining, monodansylcadaverine (MDC) staining, and transmission electron microscopy were employed to observe apoptotic bodies and autophagic vesicles. Flow cytometry with Annexin V/propidium iodide (PI) labeling objectively assessed cell death. The expression of associated proteins, including Caspase-3, Beclin-1, LC-3II, and More > Graphic Abstract

Attiya Khan¹, Muhammad Rizwan², Ovidiu Bagdasar^2,3, Abdulatif Alabdulatif^4,*, Sulaiman Alamro⁴, Abdullah Alnajim⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.3, pp. 2121-2141, 2024, DOI:10.32604/cmes.2024.054380 - 31 October 2024

Abstract The Internet of Medical Things (IoMT) is an emerging technology that combines the Internet of Things (IoT) into the healthcare sector, which brings remarkable benefits to facilitate remote patient monitoring and reduce treatment costs. As IoMT devices become more scalable, Smart Healthcare Systems (SHS) have become increasingly vulnerable to cyberattacks. Intrusion Detection Systems (IDS) play a crucial role in maintaining network security. An IDS monitors systems or networks for suspicious activities or potential threats, safeguarding internal networks. This paper presents the development of an IDS based on deep learning techniques utilizing benchmark datasets. We propose More >

Wen Zhang^1,2, Ting Wu^1,2, Xijian Chen^1,3, Hong Luo^1,2,*, Yifei Li^1,4,*

Congenital Heart Disease, Vol.19, No.4, pp. 399-406, 2024, DOI:10.32604/chd.2024.055178 - 31 October 2024

Abstract This article has no abstract. More >

Gaoyin Wu^1,#, Yundou Pang^1,#, Ya Tan¹, Zhongcheng Peng¹, Shuanggui Geng¹, Guanglin Tao², Qiuying Li¹, Shuang Wang¹, Lihong Zhang¹, Quanyan Tian¹, Yingliang Liu^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2597-2611, 2024, DOI:10.32604/phyton.2024.056875 - 30 October 2024

Abstract To establish an efficient regeneration method for the rare and endangered plant Mussaenda anomala to address problems regarding its reproductive obstacles and scarce populations. In this study, the terminal buds, axillary buds, stem segments with two axillary buds, stem segments with two axillary buds and one terminal bud, and leaves of M. anomala were used as explants. The effects of different explants and disinfection methods, plant growth regulators and substrates on plant regeneration were explored. The following results were obtained: (1) The terminal bud was a suitable explant for M. anomala tissue culture, and the disinfection method utilized… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.11, pp. 1829-1829, 2024, DOI:10.32604/or.2024.056904 - 16 October 2024

Abstract This article has no abstract. More >