Zhihai Wang*, Kui Liao†, Wenqi Zuo*, Xueliang Liu*, Zhili Qiu*, Zhitao Gong*, Chuan Liu*, Quan Zeng*, Yi Qian*, Liang Jiang*, Youquan Bu‡, Suling Hong*, Guohua Hu*
Oncology Research, Vol.25, No.1, pp. 123-136, 2017, DOI:10.3727/096504016X14732772150226
Abstract NFBD1, a signal amplifier of the p53 pathway, is vital for protecting cells from p53-mediated apoptosis and the
early phase of DNA damage response under normal culture conditions. Here we investigated its expression in
patients with nasopharyngeal carcinoma (NPC), and we describe the biological functions of the NFBD1 gene.
We found that NFBD1 mRNA and protein were more highly expressed in NPC tissues than in nontumorous tissues. To investigate the function of NFBD1, we created NFBD1-depleted NPC cell lines that exhibited decreased
cellular proliferation and colony formation, an increase in their rate of apoptosis, and More >
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