Qun Zhang, Ruixia Su, Chun Shan, Chao Gao, Pei Wu
Oncology Research, Vol.26, No.2, pp. 269-276, 2018, DOI:10.3727/096504017X15075967560980
Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Currently,
only chemoembolization and sorafenib have shown survival benefits for advanced HCC. There are major
unmet needs in HCC management and the discovery of new therapeutic targets. Here we identified NCAPG
(non-SMC condensin I complex, subunit G) as a novel mitotic gene required for HCC cell proliferation
and migration through siRNA knockdown of a panel of novel overexpressed genes in HCC based on The
Cancer Genome Atlas (TCGA) dataset. We found that knockdown of NCAPG induces HCC cell mitosis
and inhibits cell growth, More >
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