Juanjuan Yao*, Liang Zhong†, Pengqiang Zhong*, Dongdong Liu†, Zhen Yuan†, Junmei Liu*,
Shifei Yao*, Yi Zhao*, Min Chen*, Lianwen Li*, Lu Liu†, Beizhong Liu*†
Oncology Research, Vol.27, No.7, pp. 809-818, 2019, DOI:10.3727/096504018X15451301487729
Abstract RAS-responsive element-binding protein 1 (RREB1) is a transcription factor that is implicated in RAS
signaling and multiple tumors. However, the role of RREB1 in acute myeloid leukemia has not been studied.
We found that RREB1 is overexpressed in AML patients and myeloid leukemia cell lines (NB4 and HL-60),
and RREB1 expression was significantly decreased during granulocytic differentiation of myeloid leukemia
cells induced by all-trans retinoic acid (ATRA). Then we performed a RREB1 knockdown assay in NB4 and
HL-60 cells; the results showed that knockdown of RREB1 upregulated expression of CD11b, CEBP , and
microRNA-145 (miR-145), which hinted that knockdown of… More >
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