Guoqiang Zhang^*1, Zengyan Liu^†1, Yong Han^*, Xiaohong Wang^*, Zhenlin Yang^*

Oncology Research, Vol.24, No.4, pp. 233-238, 2016, DOI:10.3727/096504016X14648701447977

Abstract Triple-negative breast cancer (TNBC) is associated with high recurrence rates of metastasis and death. miR-509 has been reported to be a tumor suppressor in many cancers, but its effect in TNBC has not yet been identified. In this article, we explored the effects of miR-509 on the malignant phenotype of TNBC cells, including proliferation, apoptosis, migration, and invasion. We transiently transfected TNBC cells, Hs578T, with miR-509 mimic. Upon transfection, the expression of miR-509 was upregulated about 50-fold compared with cells transfected with scramble mimic. Overexpression of miR-509 inhibited cell proliferation, induced cell apoptosis, and suppressed More >

Ao Zhan^*, Bo Lei^*, Honggang Wu^*, YueTao Wen^†, Liandong Zheng^*, Shan Wang^*, Xiaoqiang Wan^*, Zhenghong Wei^*

Oncology Research, Vol.25, No.5, pp. 831-842, 2017, DOI:10.3727/096504016X14816726393937

Abstract Gliomas are the most common and aggressive type of primary adult brain tumors. Although GGNBP2 has previously been considered to be a tumor suppressor gene, little is known about the association between GGNBP2 and glioma. In this study, we clearly demonstrated that GGNBP2 was downexpressed in glioma tissues, and its downexpression is related to the pathological grade and overall survival of patients with gliomas. Overexpression of GGNBP2 suppressed the proliferation, migration, and invasion of glioma cells. Mechanistically, we demonstrated that the PI3K/Akt and Wnt/β-catenin signaling pathways were suppressed by GGNBP2 overexpression. In contrast, knockdown of More >

Shu Chen^*, Lianhua Jin^†, Shu Nie^†, Lizhi Han^†, Na Lu^†, Yan Zhou^†

Oncology Research, Vol.26, No.3, pp. 445-455, 2018, DOI:10.3727/096504017X14974834436195

Abstract Accumulating evidence indicates that microRNA-205 (miR-205) is involved in tumor initiation, development, and metastasis in various cancers. However, its functions in neuroblastoma (NB) remain largely unclear. Here we found that miR-205 was significantly downregulated in human NB tissue samples and cell lines. miR-205 expression was lower in poorly differentiated NB tissues and those of advanced International Neuroblastoma Staging System stage. In addition, restoration of miR-205 in NB cells suppressed proliferation, migration, and invasion and induced cell apoptosis in vitro, as well as impaired tumor growth in vivo. cAMP-responsive elementbinding protein 1 (CREB1) was identified as a More >

Abdulwadood Alawadhi^1,*, Mohd. Hasbullah Omar¹, Abdullah Almogahed², Noradila Nordin³, Salman A. Alqahtani⁴, Atif M. Alamri⁵

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2851-2878, 2024, DOI:10.32604/cmc.2024.050154

Abstract The increased adoption of Internet of Medical Things (IoMT) technologies has resulted in the widespread use of Body Area Networks (BANs) in medical and non-medical domains. However, the performance of IEEE 802.15.4-based BANs is impacted by challenges related to heterogeneous data traffic requirements among nodes, including contention during finite backoff periods, association delays, and traffic channel access through clear channel assessment (CCA) algorithms. These challenges lead to increased packet collisions, queuing delays, retransmissions, and the neglect of critical traffic, thereby hindering performance indicators such as throughput, packet delivery ratio, packet drop rate, and packet delay.… More >

Sapiah Sakri¹, Shakila Basheer¹, Zuhaira Muhammad Zain¹, Nurul Halimatul Asmak Ismail^2,*, Dua’ Abdellatef Nassar¹, Manal Abdullah Alohali¹, Mais Ayman Alharaki¹

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1157-1185, 2024, DOI:10.32604/cmc.2024.048051

Abstract Background: Sepsis, a potentially fatal inflammatory disease triggered by infection, carries significant health implications worldwide. Timely detection is crucial as sepsis can rapidly escalate if left undetected. Recent advancements in deep learning (DL) offer powerful tools to address this challenge. Aim: Thus, this study proposed a hybrid CNNBDLSTM, a combination of a convolutional neural network (CNN) with a bi-directional long short-term memory (BDLSTM) model to predict sepsis onset. Implementing the proposed model provides a robust framework that capitalizes on the complementary strengths of both architectures, resulting in more accurate and timelier predictions. Method: The sepsis prediction… More >

D. MURALI MANOHAR^1,*, B.C. CHAKRABORTY², S. SHAMSHATH BEGUM³

Journal of Polymer Materials, Vol.37, No.1-2, pp. 91-107, 2020, DOI:10.32381/JPM.2020.37.1-2.7

Abstract In search of improved materials for efficient shock and vibration mounts for machineries, graphite loaded NBR and NBR/PVC blend were made and investigated. The scorch time was seen to be reduced and vulcanization rate was enhanced due to graphite inclusion. Scanning electron microscopy images have shown homogenous dispersion of graphite powder. NBRgraphite showed a gradual increase in the hardness, tensile strength, Young’s modulus, and tear values with increasing graphite loading. In the case of NBR/PVC-graphite composition, a drop in the tensile strength and increase in the Young’ modulus and tear strength was observed. Various mathematical More >

LAVANYA, R¹, NATCHIMUTHU, N^2,*

Journal of Polymer Materials, Vol.38, No.1-2, pp. 89-100, 2021, DOI:10.32381/JPM.2021.38.1-2.8

Abstract Rubber composites of nitrile (NBR) and Ethylene-Propylene-Diene (EPDM) containing unmodified and modified microcrystalline cellulose(MCC) are evaluated for their processing behaviour. The used modified MCC (T-MCC) was treated by N,N-dimethylacetamide/lithium chloride (DMAc/ LiCl).ATR-FTIR spectra of NBR-MCC composites have indicated N-H stretching and bending vibrations and confirmed interactions between nitrile rubber and MCC. AFM studies have indicated that the average roughness of NBR-T-MCC was significantly reduced when compared to that of NBR-untreated MCC. Important processing parameters such as scorch time and cure time are found to decrease significantly for both NBR and EPDM composites withT-MCC. Mechanical properties More >

Alessandro Araldi¹, David Emsellem², Giovanni Fusco¹, Andrea Tettamanzi³, Denis Overal²

Revue Internationale de Géomatique, Vol.31, No.2, pp. 265-302, 2022, DOI:10.3166/RIG.31.265-302©2022

Abstract The identification and description of building typologies play a fundamental role in the understanding of the overall built-up form. A growing body of research is developing and implementing sophisticated, computer-aided protocols for the identification of building typologies. This paper shares the same goal. An innovative data-driven procedure for the unsupervised identification and description of building types and organization is here presented. After a specific pre-processing procedure, we develop an unsupervised clustering combining a new algorithm of Naive Bayes inference and hierarchical ascendant approaches relying on six morphometric features of buildings. This protocol allows us to More >

Shulan Lei^1,2, Shujuan Wang¹, Zhuohong Zhu^1,2, Min Lu^1,2, Xinying Li^1,2, Yiming Shen³, Jing Chen^1,2,*

International Journal of Mental Health Promotion, Vol.26, No.1, pp. 61-67, 2024, DOI:10.32604/ijmhp.2023.045478

Abstract The purpose of this study was to explore the reliability and validity of the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) among Chinese civil servants, thus establishing a useful tool for assessing the mental health of individuals in this occupation. The WEMWBS, Satisfaction with Life Scale (SWLS), and Depression Anxiety and Stress Scale-21 (DASS-21) were administered to a sample of 2,624 civil servants (42.860 ± 9.690 years) in a city located within Shandong Province, China. The findings revealed significant differences between groups with high and low scores on each item of the WEMWBS (t = 48.127–78.308, all p… More >

Zeshan Faiz¹, Iftikhar Ahmed¹, Dumitru Baleanu^2,3,4, Shumaila Javeed^1,5,6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1217-1238, 2024, DOI:10.32604/cmes.2023.029879

Abstract The purpose of this research work is to investigate the numerical solutions of the fractional dengue transmission model (FDTM) in the presence of Wolbachia using the stochastic-based Levenberg-Marquardt neural network (LM-NN) technique. The fractional dengue transmission model (FDTM) consists of 12 compartments. The human population is divided into four compartments; susceptible humans (S_h), exposed humans (E_h), infectious humans (I_h), and recovered humans (R_h). Wolbachia-infected and Wolbachia-uninfected mosquito population is also divided into four compartments: aquatic (eggs, larvae, pupae), susceptible, exposed, and infectious. We investigated three different cases of vertical transmission probability (η), namely when Wolbachia-free mosquitoes persist only… More >