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  • Open Access

    REVIEW

    Revolutionizing stem cell research: unbiased insights through single-cell sequencing

    HAO WU#, NA HUO#, SITUO WANG, ZIWEI LIU, YI JIANG*, QUAN SHI*

    BIOCELL, Vol.48, No.11, pp. 1531-1542, 2024, DOI:10.32604/biocell.2024.054278 - 07 November 2024

    Abstract Stem cells have shown great application potential in wound repair, tissue regeneration, and disease treatment. Therefore, a full understanding of stem cells and their related regulatory mechanisms in disease treatment is conducive to improving the therapeutic effect of stem cells. However, thus far, there are still many unsolved mysteries in the field of stem cells due to technical limitations, which hinder the in-depth exploration of stem cells and their wide clinical application. Single-cell sequencing (SCS) has provided very powerful and unbiased insights into cell gene expression profiles at the single-cell level, bringing exciting results to More >

  • Open Access

    ARTICLE

    Optimizing Internet of Things Device Security with a Globalized Firefly Optimization Algorithm for Attack Detection

    Arkan Kh Shakr Sabonchi*

    Journal on Artificial Intelligence, Vol.6, pp. 261-282, 2024, DOI:10.32604/jai.2024.056552 - 18 October 2024

    Abstract The phenomenal increase in device connectivity is making the signaling and resource-based operational integrity of networks at the node level increasingly prone to distributed denial of service (DDoS) attacks. The current growth rate in the number of Internet of Things (IoT) attacks executed at the time of exchanging data over the Internet represents massive security hazards to IoT devices. In this regard, the present study proposes a new hybrid optimization technique that combines the firefly optimization algorithm with global searches for use in attack detection on IoT devices. We preprocessed two datasets, CICIDS and UNSW-NB15,… More >

  • Open Access

    ARTICLE

    Structural Characterization of Chloroplast Genome in Alpinia japonica (Thunb.) Miq., a Medicinal Plant of the Genus Alpinia

    Wentao Sheng, Xi Lei, Xinjie Chen, Quan Kuang*

    Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1897-1911, 2024, DOI:10.32604/phyton.2024.052395 - 30 August 2024

    Abstract The analysis of chloroplast gene characteristics in Alpinia japonica (Thunb.) Miq. is of great significance for developing relevant genetic resources. The high-throughput sequencing and bioinformatic research were performed to analyze the chloroplast genome characteristics of A. japonica. The total chloroplast genome length of A. japonica was 161,906 bp, with a typical circular tetrameric structure. And 133 genes were annotated, comprising 87 protein-coding, 38 tRNA, and 8 rRNA genes. Furthermore, 22 genes contained two copies, and 18 genes owned introns. Repeat sequence analysis showed that it contains 321 simple sequence repeats (SSRs) and 37 long segment repeats. Compared with… More >

  • Open Access

    ARTICLE

    Dynamic Forecasting of Traffic Event Duration in Istanbul: A Classification Approach with Real-Time Data Integration

    Mesut Ulu1,*, Yusuf Sait Türkan2, Kenan Mengüç3, Ersin Namlı2, Tarık Küçükdeniz2

    CMC-Computers, Materials & Continua, Vol.80, No.2, pp. 2259-2281, 2024, DOI:10.32604/cmc.2024.052323 - 15 August 2024

    Abstract Today, urban traffic, growing populations, and dense transportation networks are contributing to an increase in traffic incidents. These incidents include traffic accidents, vehicle breakdowns, fires, and traffic disputes, resulting in long waiting times, high carbon emissions, and other undesirable situations. It is vital to estimate incident response times quickly and accurately after traffic incidents occur for the success of incident-related planning and response activities. This study presents a model for forecasting the traffic incident duration of traffic events with high precision. The proposed model goes through a 4-stage process using various features to predict the… More >

  • Open Access

    ARTICLE

    Analyzing the Wind-Dominant Electricity Market under Coexistence of Regulated and Deregulated Power Trading

    Yirui Li1, Dongliang Xiao1,3,*, Haoyong Chen1, Weijun Cai1, Josue Campos do Prado2

    Energy Engineering, Vol.121, No.8, pp. 2093-2127, 2024, DOI:10.32604/ee.2024.049232 - 19 July 2024

    Abstract Currently, both regulated and deregulated power trading exist in China’s power system, which has caused imbalanced funds in the electricity market. In this paper, a simulation analysis of the electricity market with wind energy resources is conducted, and the calculation methods of unbalanced funds are investigated systematically. In detail, the calculation formulas of unbalanced funds are illustrated based on their definition, and a two-track electricity market clearing model is established. Firstly, the concept of the dual-track system is explained, and the specific calculation formulas of various types of unbalanced funds are provided. Next, considering the More >

  • Open Access

    ARTICLE

    Silvestrol alleviates glioblastoma progression through ERK pathway modulation and MANBA and NRG-1 expression

    LAN ZHOU1,#, QI ZHANG2,#, BO TIAN1,*, FENG YANG1,*

    BIOCELL, Vol.48, No.7, pp. 1081-1093, 2024, DOI:10.32604/biocell.2024.049878 - 03 July 2024

    Abstract Background: Glioblastoma, a notably malignant tumor within the central nervous system, is distinguished by its aggressive behavior. Silvestrol, a robust inhibitor of the RNA helicase eukaryotic initiation factor 4A (eIF4A), has shown significant potential as an anticancer compound. Yet, the impact of silvestrol on glioblastoma, especially its molecular mechanisms, has not been fully elucidated. Methods: This investigation employed a variety of in vitro assays, such as cell counting kit-8 (CCK-8), clonogenic, 5-ethynyl-2′-deoxyuridine (EDU), wound healing, and flow cytometry, to evaluate cell cycle progression, apoptosis, cell viability, and migration. Western blot analysis was also performed to study… More >

  • Open Access

    ARTICLE

    DNBP-CCA: A Novel Approach to Enhancing Heterogeneous Data Traffic and Reliable Data Transmission for Body Area Network

    Abdulwadood Alawadhi1,*, Mohd. Hasbullah Omar1, Abdullah Almogahed2, Noradila Nordin3, Salman A. Alqahtani4, Atif M. Alamri5

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2851-2878, 2024, DOI:10.32604/cmc.2024.050154 - 15 May 2024

    Abstract The increased adoption of Internet of Medical Things (IoMT) technologies has resulted in the widespread use of Body Area Networks (BANs) in medical and non-medical domains. However, the performance of IEEE 802.15.4-based BANs is impacted by challenges related to heterogeneous data traffic requirements among nodes, including contention during finite backoff periods, association delays, and traffic channel access through clear channel assessment (CCA) algorithms. These challenges lead to increased packet collisions, queuing delays, retransmissions, and the neglect of critical traffic, thereby hindering performance indicators such as throughput, packet delivery ratio, packet drop rate, and packet delay.… More >

  • Open Access

    ARTICLE

    Sepsis Prediction Using CNNBDLSTM and Temporal Derivatives Feature Extraction in the IoT Medical Environment

    Sapiah Sakri1, Shakila Basheer1, Zuhaira Muhammad Zain1, Nurul Halimatul Asmak Ismail2,*, Dua’ Abdellatef Nassar1, Manal Abdullah Alohali1, Mais Ayman Alharaki1

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1157-1185, 2024, DOI:10.32604/cmc.2024.048051 - 25 April 2024

    Abstract Background: Sepsis, a potentially fatal inflammatory disease triggered by infection, carries significant health implications worldwide. Timely detection is crucial as sepsis can rapidly escalate if left undetected. Recent advancements in deep learning (DL) offer powerful tools to address this challenge. Aim: Thus, this study proposed a hybrid CNNBDLSTM, a combination of a convolutional neural network (CNN) with a bi-directional long short-term memory (BDLSTM) model to predict sepsis onset. Implementing the proposed model provides a robust framework that capitalizes on the complementary strengths of both architectures, resulting in more accurate and timelier predictions. Method: The sepsis prediction… More >

  • Open Access

    ARTICLE

    Reliability and Validity of Warwick-Edinburgh Mental Well-Being Scale among Chinese Civil Servants

    Shulan Lei1,2, Shujuan Wang1, Zhuohong Zhu1,2, Min Lu1,2, Xinying Li1,2, Yiming Shen3, Jing Chen1,2,*

    International Journal of Mental Health Promotion, Vol.26, No.1, pp. 61-67, 2024, DOI:10.32604/ijmhp.2023.045478 - 05 February 2024

    Abstract The purpose of this study was to explore the reliability and validity of the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) among Chinese civil servants, thus establishing a useful tool for assessing the mental health of individuals in this occupation. The WEMWBS, Satisfaction with Life Scale (SWLS), and Depression Anxiety and Stress Scale-21 (DASS-21) were administered to a sample of 2,624 civil servants (42.860 ± 9.690 years) in a city located within Shandong Province, China. The findings revealed significant differences between groups with high and low scores on each item of the WEMWBS (t = 48.127–78.308, all pMore >

  • Open Access

    ARTICLE

    A Novel Fractional Dengue Transmission Model in the Presence of Wolbachia Using Stochastic Based Artificial Neural Network

    Zeshan Faiz1, Iftikhar Ahmed1, Dumitru Baleanu2,3,4, Shumaila Javeed1,5,6,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1217-1238, 2024, DOI:10.32604/cmes.2023.029879 - 29 January 2024

    Abstract The purpose of this research work is to investigate the numerical solutions of the fractional dengue transmission model (FDTM) in the presence of Wolbachia using the stochastic-based Levenberg-Marquardt neural network (LM-NN) technique. The fractional dengue transmission model (FDTM) consists of 12 compartments. The human population is divided into four compartments; susceptible humans (Sh), exposed humans (Eh), infectious humans (Ih), and recovered humans (Rh). Wolbachia-infected and Wolbachia-uninfected mosquito population is also divided into four compartments: aquatic (eggs, larvae, pupae), susceptible, exposed, and infectious. We investigated three different cases of vertical transmission probability (η), namely when Wolbachia-free mosquitoes persist only… More >

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