Anqi Yin*†1, Chengguo Wang‡1, Jiachen Sun*1, Jianjun Gao§, Liang Tao†, Xilin Du‡, Huadong Zhao‡, Jiandong Yang§, Yan Li*†
Oncology Research, Vol.23, No.1-2, pp. 43-51, 2015, DOI:10.3727/096504015X14452563486093
Abstract Medullary thyroid carcinoma (MTC) is an uncommon and highly aggressive tumor of the neuroendocrine system, which derives from the neuroendocrine C cells of the thyroid gland. Except for surgical resection, there are
not very many effective systemic treatment options for MTC. N-Myc downstream-regulated gene 2 (NDRG2)
had a significantly lower expression in MTC compared with normal thyroid tissue. However, the function
of NDRG2 in MTC oncogenesis is largely unknown. In this study, we found that overexpression of NDRG2
inhibited the proliferation of TT cells (human medullary thyroid carcinoma cells) in vitro and suppressed the
development of MTC… More >
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